Association of Oxidative Stress with Disease Activity and Damage in Systemic Lupus Erythematosus: A Cross Sectional Study from a Tertiary Care Centre in Southern India     

Sanjeev Shruthi  Molly Mary Thabah  Bobby Zachariah  Vir Singh Negi 《Indian journal of clinical biochemistry : IJCB》2021,36(2):185

To study oxidative stress in systemic lupus erythematosus (SLE) by estimating serum oxidised LDL (OxLDL), 8-hydroxy-2′-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and total anti-oxidant status and to correlate with SLE disease activity and disease damage. Eighty SLE patients satisfying the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) 2012 criteria and 80 healthy controls were studied. Exclusion criteria were infections, renal insufficiency, other connective tissue diseases, drug-induced lupus, smoking, alcohol consumption. Disease activity was measured by SLE disease activity index-2 K (SLEDAI), disease damage was quantified by SLICC-Damage Index (SDI). Sera was tested for OxLDL, 8-OHdG, and total antioxidant status (TAS) by double-antibody sandwich ELISA; MDA measured by Colorimetric assay. Oxidative stress markers were compared between group1- controls, group 2-mildly active SLE (SLEDAI ≤ 5), group 3- moderate to highly active SLE (SLEDAI ≥ 6). SLE patients had significantly higher MDA, 8-OHdG and lower TAS when compared to healthy controls, while OxLDL was similar in the three groups. MDA, 8-OHdG were significantly higher, TAS lower in group 3 compared to group 2. MDA had positive correlation with SLEDAI, TAS negatively correlated with SLEDAI. SLE with neuropsychiatric manifestations, vasculitis, anti-sdDNA antibodies had higher MDA, MDA/TAS ratio. SLE patients with thrombocytopenia, and vasculitis had higher OxLDL. Only OxLDL was significantly higher in those patients who have SDI > 1. SLE patients have increased oxidative stress measured by increases in MDA, 8-OHdG, and lower total antioxidant status that was associated with disease activity and some disease manifestations. However only OxLDL was associated with damage.  相似文献   

基于认知风格调查与应激测试反馈的课程互动环节设计——以矿业特色高校工程经济类课程为例     

李鑫  周伟  席文佳  金晓红  王丽华 《煤炭高等教育》2014,(3):118-121

分析矿业特色高校涉矿类专业工程经济课程的教学模式和教学需要,利用问卷调查掌握该类高校学生的课堂表现,揭示学生课堂疲劳程度与教学体系的关系,针对该类课程教学和受众特点设计知识教授与反馈体系:在教学模块开始前引入认知风格调查手段进行心理测试,针对测试结果有针对性地设计课堂教学互动环节;同时,通过建立实验环境,利用应激测试方法,采用测试效果反馈去修改教学设计参数、改进课堂教学,从而形成动态调整的教学互动模式。  相似文献   

汽车尾板举升机构的设计及有限元分析     

程东霁  ;胡雯婷  ;雷定中  ;邬志军. 《六安师专学报》2014,(2):49-51

介绍了汽车尾板的举升机构的原理及设计方法。针对具体一款货车进行了尾板设计,绘制了三维模型,利用有限元的方法对模型做了应力分析,得出了最大应力和最大变形,均满足材料的强度和刚度的要求。本文对尾板的举升机构的研究提供了参考依据。  相似文献   

晶粒尺寸对16 Mn 钢 MnS 夹杂物的应力应变分布影响     

姜丽华  ;赖运金  ;刘晓梅  ;张利军 《渭南师范学院学报》2014,(15):26-29

基于ABAQUS有限元分析方法,对两种热处理工艺下的16 Mn钢中MnS夹杂物在同一拉伸载荷作用下的应力和应变分布进行了研究。结果表明,两种晶粒尺寸的材料在长条形MnS夹杂物附近存在着垂直于加载方向的X形状的Mi-ses应力和PEEQ集中区。但细晶的16Mn钢中MnS引起的应力和应变集中程度要明显大于粗晶的16Mn钢中MnS引起的应力和应变集中,其原因与细晶强化有关。  相似文献   

铜胁迫对小麦幼苗生长和抗氧化系统的影响     

冀玉良  高宝云 《商洛师范专科学校学报》2014,(4):3-7

以小麦种子为材料,通过液体培养实验探究铜对小麦幼苗生长和抗氧化系统的响应,揭示小麦幼苗对铜胁迫的生理抗性机制。结果表明,低浓度铜对小麦幼苗生长具有一定的促进作用,随着铜浓度的进一步增大和培养时间的延长,小麦幼苗的生长量明显减少,根和叶片中的膜脂过氧化产物丙二醛（MDA）、超氧化物歧化酶（SOD）、过氧化物酶（POD）、过氧化氢酶（CAT）和脯氨酸（Pro）的含量均明显升高,与对照相比达到5％或1％的差异显著性水平,这些活性物质在根和叶中的变化趋势基本一致,其含量除POD在根中分布大于叶中外,其余均表现为在叶中的分布大于在根中的分布。在过量Cu2＋引起胁迫的过程中,抗氧化系统各成分通过相互协同配合,对铜胁迫进行有效的抵御,对自身进行严密的保护。  相似文献   

一种新型的细孔磨料流加工机床及其加工原理分析     

王文斌  陈田  蔡红霞 《深圳职业技术学院学报》2014,(3):6-8

针对目前磨料流加工存在的问题,本文设计了一种新型的细孔磨料流加工机床.从浆料流变学的角度,推导出磨料流加工中壁面剪应力的数学表达式.结合数学表达式对其加工原理进行了分析,得出新型磨料流加工机床研磨内孔的3种主要方式.相比只存在粘性剪应力的研磨加工,新型研磨机床采用复合粘性剪应力和雷诺剪应力的工作方式,其加工效率得到明显提高.最后给出细孔磨料流加工机床在喷油器体内孔研磨加工的应用实例.  相似文献   

亨廷顿舞蹈症、氧化应激与胶质细胞     

高岩  楚世峰  陈乃宏 《河北北方学院学报(医学版)》2014,(3):22-30

氧化应激的产生与胞浆内活性氧簇的升高密切相关,过多生成的活性氧簇能够造成脂质过氧化,损伤蛋白质甚至DNA,而这些物质的受损与疾病发生相关,尤其是神经退行性疾病.神经退行性疾病经常被描述为进行性的神经元丢失,伴随神经元或者胶质细胞中出现标志性寡聚体.在神经退行性疾病中,胶质细胞可能以一种抗氧化应激的方式在神经元功能维持以及生存上发挥重要作用.反之,神经元也能够通过不同途径反馈调节胶质细胞.该文主要探讨在亨廷顿舞蹈症中胶质细胞的特点和功能,阐明氧化应激与亨廷顿舞蹈症的关系,概括这三者之间的关系进而论证胶质细胞在亨廷顿舞蹈症中的抗氧化应激保护作用.  相似文献   

奖学金制度下压力转化对研究生的影响     

童薇 《成都航空职业技术学院学报》2014,30(3):75-80

研究采用自编问卷对4所大学的研一学生进行调查,探讨了奖学金制度下,研究生的压力体验及其调试,结果发现：不同家庭经济状况、性别和入学获得奖学金等级的研究生其奖学金制度压力、压力转化及对其学习生活的影响不同;研究生的压力大小不同、压力转化方式不同,对其学习生活的影响也不同。  相似文献   

Deformation mechanism of high-stress and broken-expansion surrounding rock and supporting optimization based on the gray correlation theory     

YU Wei-jian  WANG Ping  DU Shao-hua 《重庆大学学报(英文版)》2014,13(3):99-114

Aiming at the large deformation and support problems of high-stress and broken-expansion surrounding rock, and taking 1 000 m level roadway of Mine II in Jinchuan as the research object, an investigation on the deformation and damage of roadway surrounding rock and an analysis of its mechanism were carried out. The gray correlation theory was used in support scheme optimization design. First, causes and mechanism of deformation of the 1 000 m horizontal transport channel were analyzed through field investigation, laboratory test and data processing methods. We arguued that poor engineering geological conditions and deep pressure increases were the main factors, and the deformation mechanism was mainly the ground deformation pressure. Second, the gray correlation theory was used to construct supporting optimization decision method in the deep roadway. This method more comprehensively considers various factors, including construction, costs, and supporting material functions. The combined support with pre-stressed anchor cables, shotcrete layer, bolt and metal net was put forward according to the actual roadway engineering characteristics. Finally, 4 support schemes were put forward for new roadways. The gray relational theory was applied to optimizing the supporting method, undertaking technical and economic comparison to obtain the correlation degree, and accordingly the schemes were evaluated. It was concluded as follows： the best was the flexible retaining scheme using the steel strand anchor; the second best was the one using plate anchors on the top and rigid common screw steel bolt on the two sides; the ttiird was; the rigid common screw steel bolt in full section of roadway; and the worst is the planished steel rigid support. The optimized scheme was applied to the 1000 m level of new excavation roadway. The results show that the roadway surrounding rock can reach a stable state after 5 to 6 months monitoring, with a convergence rate less than 1 mm/d.  相似文献   

地基附加应力计算与可视化技术方法     

薛奕忠  蔡伟 《莆田学院学报》2014,(5):78-82

为实现快速准确的地基土层中附加应力计算,整体分析地基土层中附加应力的分布规律,应用数值和图形方法对工程中多种常用工况进行系统计算和可视化分析,避免工程计算中需要的查表和插值等,计算方法和可视化结果可直接应用于工程设计和基本土力学问题分析。  相似文献