线上教学的探索与实践     

初瑞瑶 《成才之路》2021,(1)

线上教学这种新兴教学模式可以突破时间和空间的限制,便于学生随时随地进行学习,可以丰富课堂教学内容,营造良好的教学氛围,可以培养学生自主学习的能力,提高学生分析问题和解决问题的能力。文章以“0-3岁婴幼儿保育与教育”课程为例,探讨线上教学的教学思路、技术手段、教学组织与实施、应用效果、突出亮点等内容。  相似文献   

疫情背景下大学生心理韧性与焦虑的关系:应对方式的作用          下载免费PDF全文

孙道凯廖传景余如英 《宁波大学学报(教育科学版)》2021,(6):114-121

为考察新冠疫情背景下大学生心理韧性与焦虑的关系,以及应对方式在其中的作用,使用心理韧性量表（CD-RISC）、广泛性焦虑量表（GAD-7）、特质应对方式问卷（TCSQ）采取问卷星线上的方式共得到1198份有效问卷。结果发现:1198份数据中无焦虑症状762人（63.6%）,轻度焦虑398人（33.2%）,中度焦虑30人（2.5%）,重度焦虑8人（0.7%）;女生在焦虑上的得分显著高于男生,学历、年级和居住地在焦虑上的得分并无显著性差异;大学生心理韧性及其各维度与焦虑存在显著水平的负相关,心理韧性及其各维度和积极应对方式呈显著正相关,和消极应对方式呈显著负相关,积极的应对方式与焦虑呈显著负相关,而消极的应对方式与焦虑呈显著正相关;大学生的积极应对方式和消极应对方式在心理韧性对焦虑的影响中具有完全中介作用。因此新冠疫情背景下,大学生心理韧性是通过积极应对方式和消极应对方式间接影响其焦虑水平。  相似文献   

3—6岁幼儿家庭户外活动现状及优化对策——以青岛市城阳区为例     

初瑞瑶  栾晓辉 《林区教学》2021,(3)

幼儿天生就爱在户外玩耍,户外活动不仅能促进幼儿身体的健康发育,而且能够有效促进幼儿社会性以及智力的发展,家庭户外活动更能促进亲子间的感情。通过文献法、问卷调查法、访谈法对幼儿家庭户外活动进行六方面的调查,包括幼儿家庭户外活动的时间、场所、内容、伙伴、家长参与情况以及家长态度。研究发现,幼儿家庭户外活动存在家长对幼儿户外活动认识不足、幼儿户外活动场地和内容局限单一以及存在诸多安全隐患等问题。建议家长应合理规划,增加幼儿户外活动的多样性和趣味性;注重参与,优化幼儿户外活动的体验与成效;多重保障,提升幼儿户外活动的安全性。  相似文献   

Attention‐Deficit/Hyperactivity Disorder Symptoms,Perceived Stress,and Resilience in College Students     

Stacey L. Hamilton  Amanda Baraldi  Shelia M. Kennison 《Journal of College Counseling》2021,24(1):49-62

This research investigated the relationships among symptoms associated with attention‐deficit/hyperactivity disorder (ADHD), perceived stress, and resilience in college students. In our study of 558 college students (175 men, 383 women), we confirmed the hypothesis that the relationship between ADHD symptoms and perceived stress is mediated by protective factors associated with resilience. The relationships were not significantly moderated by sex. Implications for increasing resilience in college students and lowering perceived stress for college students are discussed.  相似文献   

CHOP及GRP78在复发性多形性胶质母细胞瘤患者表达显著增加     

文雪 《孝感职业技术学院学报》2021,(1):108-112

目的:研究CHOP及GRP78与复发性GBM的相关性。方法:采用Western blot检测CHOP及GRP78在初发及复发GBM组织中的表达;Real-time PCR检测GRP78在初发以及复发GBM组织中的表达。结果:CHOP及GRP78在初发GBM中表达上调,而在经过原发性肿瘤切除后接受放疗和替莫唑胺化疗的复发性GBM中增加尤为显著。结论:CHOP及GRP78在GBM发病机制中起重要作用,该分子有望成为GMB潜在的诊断及预后评估标志物。  相似文献   

CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement     

Li  Chao  Brant  Eleanor  Budak  Hikmet  Zhang  Baohong 《Journal of Zhejiang University. Science. B》2021,22(4):253-284

Since it was first recognized in bacteria and archaea as a mechanism for innate viral immunity in the early 2010 s,clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas) has rapidly been developed into a robust, multifunctional genome editing tool with many uses. Following the discovery of the initial CRISPR/Cas-based system, the technology has been advanced to facilitate a multitude of different functions. These include development as a base editor, prime editor, epigenetic editor, and CRISPR interference(CRISPRi) and CRISPR activator(CRISPRa) gene regulators. It can also be used for chromatin and RNA targeting and imaging. Its applications have proved revolutionary across numerous biological fields, especially in biomedical and agricultural improvement. As a diagnostic tool, CRISPR has been developed to aid the detection and screening of both human and plant diseases, and has even been applied during the current coronavirus disease 2019(COVID-19) pandemic. CRISPR/Cas is also being trialed as a new form of gene therapy for treating various human diseases, including cancers, and has aided drug development. In terms of agricultural breeding, precise targeting of biological pathways via CRISPR/Cas has been key to regulating molecular biosynthesis and allowing modification of proteins, starch, oil, and other functional components for crop improvement. Adding to this, CRISPR/Cas has been shown capable of significantly enhancing both plant tolerance to environmental stresses and overall crop yield via the targeting of various agronomically important gene regulators. Looking to the future, increasing the efficiency and precision of CRISPR/Cas delivery systems and limiting off-target activity are two major challenges for wider application of the technology. This review provides an in-depth overview of current CRISPR development, including the advantages and disadvantages of the technology,recent applications, and future considerations.  相似文献   

Osteogenic effects of antihypertensive drug benidipine on mouse MC3T3-E1 cells in vitro     

Wang  Baixiang  Yang  Jiakang  Fan  Lijie  Wang  Yu  Zhang  Chenqiu  Wang  Huiming 《Journal of Zhejiang University. Science. B》2021,22(5):410-420

Hypertension is a prevalent systemic disease in the elderly, who can suffer from several pathological skeletal conditions simultaneously, including osteoporosis. Benidipine(BD), which is widely used to treat hypertension, has been proved to have a beneficial effect on bone metabolism. In order to confirm the osteogenic effects of BD, we investigated its osteogenic function using mouse MC3 T3-E1 preosteoblast cells in vitro. The proliferative ability of MC3 T3-E1 cells was significantly associated with the concentration of BD, as measured by methylthiazolyldiphenyl-tetrazolium bromide(MTT)assay and cell cycle assay. With BD treatment, the osteogenic differentiation and maturation of MC3 T3-E1 cells were increased,as established by the alkaline phosphatase(ALP) activity test, matrix mineralized nodules formation, osteogenic genetic test,and protein expression analyses. Moreover, our data showed that the BMP2/Smad pathway could be the partial mechanism for the promotion of osteogenesis by BD, while BD might suppress the possible function of osteoclasts through the OPG/RANKL/RANK(receptor activator of nuclear factor-κB(NF-κB)) pathway. The hypothesis that BD bears a considerable potential in further research on its dual therapeutic effect on hypertensive patients with poor skeletal conditions was proved within the limitations of the present study.  相似文献   

网络环境下有效学习行为特征及影响因素研究     

黄家荣  曹榴 《教育与教学研究》2021,(4):41-52

在网络环境下,学习者由于高度自由同时又缺乏有效的监管,学习很容易受到外界事件的干扰,并不能完全保证学习者的学习行为是有效的。为保证网络环境下学习的质量与绩效,有必要对网络环境下的有效学习行为进行深入研究。文章在“有效学习”定义基础上,提出网络环境下有效学习行为的概念及其特征,并详细讨论了网络环境下有效学习行为的主要影响因素,最后从中得到提高网络环境下学习行为有效性的启示:在课前,教师要做好学前分析,检查学习者是否已有本次学习必要的基础知识储备,并帮助学习者明确自己的学习目标,给学习者提供必要的学习环境;在课中,教师要注重学习者信息技术应用能力的培养,同时给学习者施加一定的外部动机,并结合具体情况,给予学习者有效的引导;在课后,教师需要及时对这节课进行反思总结。  相似文献   

中央信息管理与网络经济的宏观调控机制研究   总被引：4，自引：1，他引：4  

侯经川 《情报理论与实践》2005,28(1):13-17,47

在前期研究的基础上，本文探讨了构建中央信息库的必要性及其可能的构建方式与结构模型，设计了它对网络信息活动和网络经济运行的宏观调控机制。  相似文献   

国外高技术企业运用专利制度的策略及趋势研究   总被引：2，自引：0，他引：2  

叶苏  顾新  杨早林  唐琳 《软科学》2005,19(4):84-87

分析了国外高技术企业运用专利制度的策略,预测了国外高技术企业运用专利制度的趋势,为我国高新技术企业提供借鉴。  相似文献