Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Identifying the combinations of motivations and emotions for creating satisfied users in SNSs: An fsQCA approach     

《International Journal of Information Management》2020

Social Networking Sites (SNSs) play an important role in our daily lives and the number of their users increases regularly. To understand how users can be satisfied in the complex digital environment of SNSs, this study examines how motivations and emotions combine with each other to explain high satisfaction. Users’ motivations comprise four attributes, entertainment, information, social-psychological, and convenience. Emotions are divided into their two main categories, that is positive and negative emotions. We draw on complexity and configuration theories, present a conceptual model along with propositions and perform a fuzzy-set qualitative comparative analysis (fsQCA). Through an empirically study with 582 SNSs users, we present eight combinations (configurations) of motivations and emotions that lead to high satisfaction, which highlight the role of high convenience, followed by entertainment and information motivations in being satisfied with SNSs. High satisfaction can be achieved both when positive and negative emotions are high and low, depending on how they combine users’ motivations. None of the factors are indispensable to explain high satisfaction on their own, instead they are insufficient but necessary parts of the causal combinations that explain high satisfaction. This study contributes in SNSs literature by extending current knowledge on how motivations and emotions combine to increase satisfaction, and by identifying specific patterns of users for whom these factors are important and influence greatly their satisfaction.  相似文献   

Data Visualization as Participatory Research: A Model for Digital Collections to Inspire User-Driven Research     

A. Miller 《Journal of Web Librarianship》2019,13(2):127-155

The emerging creative practices of digital collections are increasing in prominence thanks to the access to, and appeal of, data visualizations. Interactive data visualizations, such as a map, timeline, chart, graph, or artist’s rendering of data, enable users to pursue their own research interests within a collection and participate in new areas of research. Use of these data visualizations enhances the scope of the collection and enables a modern and diverse thematic collection to emerge. This article considers the question: Does the addition of data visualizations affect how users participate with a research collection? Impacts on collection development, application of user-centered design, and analysis of users’ exploratory strategies are discussed. Examples of data visualizations used in digital humanities projects and digital collections are presented as case studies.  相似文献   

离岸集装箱码头新装卸工艺模式下陆域集疏运堆场堆存空间分配     

杨晓斌  余思勤  沈一帆 《上海海事大学学报》2020,41(4):8-14

离岸集装箱码头因其岛屿面积限制，难以通过扩建码头内部堆场增加吞吐能力。为解决这个问题，提出一种离岸集装箱码头新装卸工艺模式。新装卸工艺模式是通过在离岸集装箱码头附近的陆域地带建设陆域集疏运堆场,与离岸集装箱码头进行协同装卸作业的模式。陆域集疏运堆场堆存空间分配的目标是满足离岸集装箱码头装卸作业预翻倒要求;单批次输送集装箱的量受到陆岛运输最大通行能力限制。根据上述目标与特点，构建新装卸工艺模式下陆域集疏运堆场堆存空间分配模型，并设计蒙特卡洛树搜索算法进行求解。通过算例分析验证模型的有效性。结果表明该方法能够满足陆域集疏运堆场堆存空间分配需求并提高离岸集装箱码头的吞吐能力。  相似文献   

协同搜索过程中用户交流内容与模式研究     

张璐  张鹏翼  刘畅 《图书情报知识》2020,(3):51-62

[目的/意义]旨在分析协同搜索用户在信息搜索任务过程中的交流内容与模式,从而理解协同搜索用户的关注重点与搜索过程。[研究设计/方法]基于书籍交互检索平台(CLEF-Social Book Search)设计实验,共招募18名被试完成两种搜索任务,通过录音记录对话并对其进行编码和分析,总结交流内容特征和模式。结合任务类型、认知类型组合、服务器记录的搜索交互行为日志以及问卷收集的搜索体验进行了探索分析。[结论/发现]从交流内容上看,协同搜索用户主要理解与评判书目信息、商讨搜索任务计划;比起认知类型不同的用户,相同认知类型的用户在操作交互方面交流更多,在评判决策方面交流较少。交流模式依据讨论内容比重可分为理解评判型、评判主导型、均衡交流型三种,评判主导型用户的任务完成满意度最高。[创新/价值]协同搜索用户的交流反映出搜索过程中需要与同伴商讨协同的焦点,也是需要系统提供协助的重点,给协同搜索系统设计提供一定参考。本研究针对协同搜索的交流内容设计的编码系统对相关的协同交流研究也有借鉴意义。  相似文献   

Beyond traditional collaborative search: Understanding the effect of awareness on multi-level collaborative information retrieval     

Nyi Nyi Htun  Martin Halvey  Lynne Baillie 《Information processing & management》2018,54(1):60-87

Although there has been a great deal of research into Collaborative Information Retrieval (CIR) and Collaborative Information Seeking (CIS), the majority has assumed that team members have the same level of unrestricted access to underlying information. However, observations from different domains (e.g. healthcare, business, etc.) have suggested that collaboration sometimes involves people with differing levels of access to underlying information. This type of scenario has been referred to as Multi-Level Collaborative Information Retrieval (MLCIR). To the best of our knowledge, no studies have been conducted to investigate the effect of awareness, an existing CIR/CIS concept, on MLCIR. To address this gap in current knowledge, we conducted two separate user studies using a total of 5 different collaborative search interfaces and 3 information access scenarios. A number of Information Retrieval (IR), CIS and CIR evaluation metrics, as well as questionnaires were used to compare the interfaces. Design interviews were also conducted after evaluations to obtain qualitative feedback from participants. Results suggested that query properties such as time spent on query, query popularity and query effectiveness could allow users to obtain information about team's search performance and implicitly suggest better queries without disclosing sensitive data. Besides, having access to a history of intersecting viewed, relevant and bookmarked documents could provide similar positive effect as query properties. Also, it was found that being able to easily identify different team members and their actions is important for users in MLCIR. Based on our findings, we provide important design recommendations to help develop new CIR and MLCIR interfaces.  相似文献   

电视新闻策划的实践思考     

夏冰 《浙江传媒学院学报》2003,10(3):18-20

新闻策划是对新闻报道活动的策划,电视新闻策划是现代社会受众和电视自身发展的需要。电视新闻的策划重在发挥电 视传播的优势,强调整体的协作。  相似文献   

中国传统文化与学校体育可持续发展   总被引：2，自引：0，他引：2  

吴刚 《湖北体育科技》2003,22(2):156-157,160

中国传统文化是学校体育可持续发展的外环境因素，它主要由儒家、道家和禅宗文化构成，具有中庸和平、泛道德性、人文精神、非独立性、静止停滞、乡土情结等特质，通过研究它的理性因素对学校体育可持续发展的正面影响和非理性因素带来的负面影响，来探讨在学校体育思想、内容和方法上应采取的发展对策。  相似文献   

GM(1,h)系统状态模型在田径训练中的应用   总被引：4，自引：0，他引：4  

刘嘉津  孙桂云 《上海体育学院学报》2003,27(1):78-81,F003

将多因素整体状态GM（1，h)模型及其特列GM（1，1）模型结合起来，用于高水平田径训练的建模问题研究，使建立的系统模型既能反映系统内部多因素的整体关系，又能满足超前预测和规划的需要，旨为田径训练提供了一种有效的科学方法。  相似文献   

竞争情报与知识管理关系浅析   总被引：20，自引：5，他引：15  

秦铁辉  舒文芳  晏创业 《图书情报工作》2003,47(11):28-31

在分析竞争情报、知识管理的共性和相异性的基础上,论述两者之间的交叉、互融关系,并提出建立一种两者之间的良性互动机制提升企业的竞争力。  相似文献