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Anuradha Bharosay Vivek Vikram Bharosay Kiran Saxena Meena Varma 《Indian journal of clinical biochemistry : IJCB》2018,33(2):178-183
This study was undertaken to evaluate the role of serum neuron specific enolase (NSE) in prediction of disability and neurological worsening in hypertensive ischemic cerebrovascular stroke. 80 hypertensive ischemic stroke patients diagnosed by a neurologist as per WHO definition along with radiological findings suggestive of cerebrovascular stroke and differentiating from hemorrhagic stroke and 60 controls having essential hypertension coming to hospital because of regular checkup or headache but with no neurological disease were included in the study. Neurological disability was assessed by NIHSS at the time of admission (within 72 h from the onset of stroke) and on 7th day after admission and cases were categorized into mild, moderate and severe disability. Venous blood samples were drawn within 72 h from the onset of symptoms. The samples were processed as per the laboratory protocol. The serum NSE samples were analyzed using an enzyme immunoassay based on the sandwich technique. We observed raised serum NSE in hypertensive ischemic stroke (17.4 ± 5.4 ng/ml) with significant association between different hypertensive groups than in hypertensive controls (9.1 ± 0.75 ng/ml). Greater degree of disability was observed in hypertensive stroke patients with raised serum NSE and hypertensive patients with mean serum NSE level of 22.9 ± 3.6 ng/ml and dyslipidemia had greater probability of neurological worsening as compared to those with mean serum NSE level of 12.7 ± 1.2 ng/ml. Serum NSE levels can serve as a peripheral indicator of neuronal damage and assist in the prediction of disability and clinical outcome in hypertensive cerebrovascular ischemic stroke patients. 相似文献
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R. P. Saxena 《Higher Education》1990,20(1):91-111
India with a current student population of around 4 million in its universities and colleges is the third largest system in the world after USA and USSR. The unprecedented expansion of higher education in India, which took place in the last four decades, has, however, been extremely uneven and resulted in the neglect of quality, research and managements aspects. The universities and colleges function much below their optimal levels and fail even to fulfil their minimum and basic tasks such as making admissions, completing teaching, conducting examinations, declaring results and awarding degrees on time. The very credibility of the university system stands eroded.Increasing government control, extra-constitutional pressures in their governance, appointment and dismissal of Vice-Chancellors on political considerations and drift of the academic community from serious academic pursuits have undermined the autonomy of the universities. The paper attempts to analyse from macro-micro angles the causes for the decay of the university system.The National Policy on Education-1986 aims at radical reorganisation of higher education to bring about dynamism in the system through multi-pronged strategies and programmes and structural reforms. Policy interventions have, however, failed to create much impact. The paper brings forth some of the important issues vital to the governance of the universities and highlights the need for a collective endeavour of teachers, students, educational administrators and government and rigorous system of performance audit to bring dynamism into the system. 相似文献
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Ishrat Husain Ramesh Chander Jitendra Kumar Saxena Abbas Ali Mahdi Farzana Mahdi 《Indian journal of clinical biochemistry : IJCB》2015,30(1):72-77
The antidyslipidemic activity of Ocimum sanctum leaf extract was studied in streptozotocin induced diabetic rats. In this model, there was significant increase in plasma markers of diabetic-dyslipidemia following diminution of lipid metabolizing enzymes. Oral administration of leaf extract (500 mg/kg b.w.p.o.) for 15 days resulted in significant decrease in diabetogenic and dyslipidemia parameters; namely blood glucose, glycosylated hemoglobin, lipid peroxide, free fatty acids, small dense low density lipoprotein, lipid and protein components of plasma lipoproteins, adipose and liver. The regulation of lipids was accompanied by stimulation of postheparin lipolytic activity, reactivation of lecithin cholesterol acyl transferase and hepatic lipoprotein lipase enzymes. The results of the present study demonstrated antidyslipidemic and antioxidant activities in leaf extract of O. sanctum which could be used in prevention of diabetic-dyslipidemia and related complications. 相似文献
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Sudhesna Mohapatra Teresa Biswas Saswati Das Alpana Saxena 《Indian journal of clinical biochemistry : IJCB》2014,29(1):112-113
Alkaptonuria or ochronosis is a rare inborn disorder of metabolism which is characterized by deficiency of homogentisic acid oxidase. There is accumulation of homogentisic acid in the connective tissues causing brownish black pigmentation and skeletal damage. The most serious complication of this disease is crippling degenerative arthropathy which presents in late years of life. There is no definitive treatment for the condition. Symptomatic management is the main stay. Surgical management such as arthroplasty is done for severe cases of ochronosis. We report a case of ochronosis of the hip joint presenting with inflammation and lytic lesion which can create confusion and lead to error in diagnosis. 相似文献
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Mala Mahto Sudhesna Mohapatra G. Sumitra Smita Kaushik T. K. Mishra Alpana Saxena 《Indian journal of clinical biochemistry : IJCB》2011,26(4):420-422
Light chain disease is a variant of multiple myeloma in which the malignant population of marrow cells produces free monoclonal
light chains but no heavy chain or complete immunoglobulin. The monoclonal light chains are small enough to be freely filtered
by the kidneys and become Bence–Jones protein. Light chain disease comprises about 18% of multiple myeloma patients. Here
we present a case report of a 38-year-old man who initially presented with complaints of pain in back and low grade fever
off and on. He was found to have collapse of D9 and D12 vertebrae along with ascites and right pleural effusion and massive
proteinuria. Multiple myeloma was considered as a differential diagnosis based on the investigations but eventually the patient
was lost to follow up. This case is reported here as the light chain variant of multiple myeloma leading to deposition disease
is less commonly reported and presents considerable difficulties in diagnosis. 相似文献
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Using Polymerase Chain Reaction followed by Single Strand Conformation Polymorphism analysis, we studied thirty seven cases
of primary human breast cancer for the presence of mutations in exons 5 and 7 of p53 tumour suppressor gene. Only one of the
thirty seven tumours tested (2.7%) showed the electrophoretic mobility shift indicative of a mutation in exon 5 of the p53gene,
while no such mobility shift was noted in exon 7. Our finding is in contrast to the findings in previous studies, wherein
the mutation frequency has been reported to be 13–30% by direct DNA analysis. This may be related to the ethnicity and local
population prevalence rather than technique. 相似文献
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‘Return to school’ for enhancement of career is considered a means to career mobility. However, if ‘return to school’ is chosen after a certain stage it has its own costs and challenges. It becomes more complex, especially for women, if geographical distance from family becomes an additional variable to it. Present study, grounded in Indian context, examines married Indian women professionals, who opted for geographical separation from their families (including, in some cases, infants and small children) to pursue higher studies. The study explores what spurs well-qualified married women professionals to take a career break and join a rigorous educational programme which requires them to stay away from their families for a substantial time. Key themes that emerged from the study can be categorised as motives: dissatisfaction with work situation, need for skill enhancement, and an urge to develop one’s own identity; facilitators: support and encouragement from spouse and other family members and age; challenges faced: psychological turmoil, strain on relationships, and financial stress. 相似文献