Serum adenosine deaminase, 5′ nucleotidase and malondialdehyde in acute infective hepatitis     

K. Pratibha  Usha Anand  Rajni Agarwal 《Indian journal of clinical biochemistry : IJCB》2004,19(2):128-131

Serum adenosine deaminase (ADA), 5′ nucleotidase (5′NT) and malondialdehyde (MDA) were estimated in patients with acute infective hepatitis (AIH) along with the routine parameters of liver disease. Present study is done to evaluate these special parameters in patients with clinical history of AIH and to assess the utility of these parameters as diagnostic/ prognostic indices of liver function and to correlate special parameters with routine live function tests (LFT). ADA, 5′NT and MDA along with routine LFT was estimated in 25 patients with AIH and 25 samples from healthy voluntary blood donars served as the control group. Routine LFT was estimated by standard clinical chemistry procedures on dade behring analyser and ADA, 5′NT and MDA were estimated by berthlot reaction, fiske and subbarao method and thiobarbituric acid method respectively. Statistical analysis showed that serum ADA, 5′NT and MDA were significantly higher in patients as compared with the controls. There was a significant positive correlation between ADA and total bilirubin and MDA and total bilirubin. Hence we can conclude that these tests would be more sensitive to diagnose the patients with AIH and that the raised bilirubin levels could be looked upon, as a protective mechanism which the liver has evolved in order to combat oxidative stress.  相似文献   

Understanding,embracing and reflecting upon the messiness of doctoral fieldwork     

Arif Naveed  Nozomi Sakata  Anthoula Kefallinou  Sara Young  Kusha Anand 《Compare》2017,47(5):773-792

This Forum issue discusses the centrality of the fieldwork in doctoral research. The inevitability of researchers’ influence and of their values apparent during and after their fieldwork calls for a high degree of reflexivity. Since the standard methodology textbooks do not sufficiently guide on addressing such challenges, doctoral researchers go through stressful phases, at times revising various decisions they made before starting fieldwork. By drawing upon four case studies from varied contexts, this forum highlights some of these challenges including: going beyond signing the consent form and building rapport to elicit student voices; the ethical implications of White privilege of researchers turning consent into an obligatory contract with participants; unanticipated delays in the fieldwork opening up new possibilities; and tensions resulting from negotiating between insider and outsider identities while researching in two hostile contexts.  相似文献   

Health informatics program design and outcomes: Learning from an early offering at a mid-level university     

Kevin R. Parker  Sankara Subramanian Srinivasan  Robert F. Houghton  Nima Kordzadeh  Karoly Bozan  Thomas Ottaway  Bill Davey 《Education and Information Technologies》2017,22(4):1497-1513

Curriculum development is particularly challenging in computing-related disciplines as the computing industry changes more quickly than most. As information technology degrees have become relatively pervasive, some institutions that offer information systems degrees have recognized a need to develop specialist studies in information systems. This detailed case study shows the forces related to a successful implementation of new Health Informatics degrees. The case describes both an unsuccessful and then a successful attempt at essentially the same curriculum development. Although the case includes some local political factors, these represent typical considerations that a curriculum developer is likely to encounter.  相似文献   

Computer based modelling and simulation     

N. K. Srinivasan 《Resonance》2001,6(4):69-77

Most systems involve parameters and variables, which are random variables due to uncertainties. Probabilistic methods are powerful in modelling such systems. In this second part, we describe probabilistic models and Monte Carlo simulation along with ‘classical’ matrix methods and differential equations as most real situations are complex (with several variables) and involve uncertainties.  相似文献   

Sadi Carnot and the second law of thermodynamics     

J Srinivasan 《Resonance》2001,6(11):42-48

The second law of thermodynamics is one of the enigmatic laws of physics. Sadi Carnot, a French engineer played an important role in its discovery in the 19th century. We recount here how he proposed the basic postulates of this law although he did not fully understand the first law of thermodynamics.  相似文献   

Myeloperoxidase in Chronic Kidney Disease     

Madhusudhana Rao A  Anand U  Anand CV 《Indian journal of clinical biochemistry : IJCB》2011,26(1):28-31

Numerous lines of evidence implicate a role of myeloperoxidase (MPO) in the pathogenesis of cardiovascular disease (CVD). It is a well accepted fact that patients with chronic kidney disease (CKD) are at an increased risk for CVD. MPO is a pro-oxidant enzyme which could be involved in the increased susceptibility of these patients to CVD. Hence, the levels of plasma MPO was determined in healthy controls as well as in patients with CKD [stratified with the level of their kidney failure as CKD stages II–V (end stage renal disease)]. Plasma MPO was assayed by a spectrophotometric method. Serum urea and creatinine were estimated on a clinical chemistry analyzer using standard laboratory procedures. The mean plasma MPO levels were significantly lower with advancing stages of renal failure (P < 0.001). There was a positive correlation between MPO and GFR (r = +0.89, P < 0.001) and a negative correlation with urea (r = −0.85, P < 0.001) and creatinine (r = −0.82, P < 0.001). While an inverse association was observed between plasma MPO and urea in CKD patients, such an association was not observed in control subjects (P = 0.43). In conclusion, the decline in plasma MPO levels may be due to the inhibitory effect of uraemic toxins on the enzyme.  相似文献   

A simple design method for the cosine-modulated filter banks using weighted constrained least square technique   总被引：1，自引：0，他引：1  

A. Kumar  G.K. Singh  R.S. Anand 《Journal of The Franklin Institute》2011,348(4):606-621

This paper presents a simple and efficient design method for cosine-modulated filter banks with prescribed stopband attenuation, passband ripple, and channel overlap. The method casts the design problem as a linear minimization of filter coefficients such that their value at ω=π/2M is 0.707, which results in a simpler, more direct design procedure. The weighted constrained least squares technique is exploited for designing the prototype filter for cosine modulation (CM) filter banks. Several design examples are included to show the increased efficiency and flexibility of the proposed method over the exiting methods. An application of the proposed method is considered in the area of sub-band coding of the ECG and speech signals.  相似文献   

VDR,RXR, Coronin-1 and Interferonγ Levels in PBMCs of Type-2 Diabetes Patients: Molecular Link between Diabetes and Tuberculosis     

Kirtimaan Syal  Anand Srinivasan  Dibyajyoti Banerjee 《Indian journal of clinical biochemistry : IJCB》2015,30(3):323-328

Diabetes and tuberculosis are world’s most deadly epidemics. People suffering from diabetes are susceptible to tuberculosis. Molecular link between the two is largely unknown. It is known that Vitamin A receptor (RXR) heterodimerizes with Vitamin D receptor (VDR) and Peroxisome proliferator-activator receptor-γ (PPARγ) to regulate Tryptophan-aspartate containing coat protein (TACO) expression and fatty acid metabolism respectively, so it would be interesting to check the expression of these genes in diabetes mellitus (DM) patients which might explain the susceptibility of diabetics to tuberculosis. In this study, we checked the expression of RXR, VDR, TACO and Interferon-γ (IFNγ) genes in type-2 DM patients for understanding the link between the two diseases. We observed down regulation of RXR gene and corresponding up regulation of TACO gene expression. We have not observed significant change in expression of VDR and IFNγ genes in type-2 DM patients. Repression of RXR gene could hamper VDR-RXR heterodimer formation and thus would up regulate TACO gene expression which may predispose the type-2 DM patients to tuberculosis. Also, decrease in RXR-PPARγ heterodimer could be involved in DM.  相似文献   

Transformative learning in designing algorithms for reporting information systems     

Anand Jeyaraj 《Education and Information Technologies》2018,23(4):1699-1717

This paper describes a teaching method that enables students to design efficient and effective algorithms for reporting information systems applications. Adopting the general principles of transformative learning, students are immersed in a series of activities and interventions to enable learning. The activities provided opportunities for students to design algorithms, also using knowledge gained during the interventions. The interventions allowed students to gain knowledge about the output data structures such as list, table, and cube; the sequence control structures that may take different execution times; and the assumptions such as source data tables and mapping rules—all of which can contribute to the design of efficient and effective algorithms. 88 undergraduate business students in an advanced information systems course learn the principles of designing algorithms through critical reflection and reinterpretation consistent with the principles of transformative learning. The algorithms designed by students reveal that attention to the output data structures, sequence control structures, and assumptions enables the design of efficient and effective algorithms.  相似文献   

Effect of oral antioxidant supplementation on lipid peroxidation during radiotherapy in head and neck malignancies     

Anissa Kaleemullah Shariff  Sangita R. Patil  Pramod S. Shukla  Ajit V. Sontakke  Anup S. Hendre  Anand K. Gudur 《Indian journal of clinical biochemistry : IJCB》2009,24(3):307-311

The objectives of the present study were to ascertain the variations in the serum levels of malondialdehyde and total antioxidant status, in head and neck malignancies with different stages, with and without oral antioxidant supplementation, before and after radiotherapy, and to validate the protective effects of an antioxidant supplementation during radiotherapy. The pretreatment values of serum malondialdehyde were significantly raised, while that of serum total antioxidant status were significantly declined in all the stages of head and neck malignancies, when compared with the healthy controls values (P<0.001). A significant correlation was observed related to the studied parameters and different stages of the disease. The study suggests that an oral antioxidant supplementation during radiotherapy is an effective mode in reducing oxidative stress. Antioxidant supplementation during radiotherapy may serve as an adjuvant therapy in malignancies offering a protection to normal cells that may further reduce the risk of developing secondary cancers.  相似文献