排序方式： 共有91条查询结果，搜索用时 15 毫秒
1.
急性白血病相关基因的文本挖掘分析 总被引：2，自引：0，他引：2
从PubMed检索1966年到2005年9月6日间白血病与基因关系的相关文献3 529篇.经编程处理生成主题词词篇矩阵并进行聚类.通过聚类树图可将所提取的主题词/副主题词分成13类,经对比原始文献进行验证,全部29种基因中只与ALL相关的有3种, 占10.34%;只与AML相关的有8种,占27.59%.特异的可用于鉴别ALL和AML的基因有11种,占37.93%.通过主题词的共现关系进行聚类可以基本实现发现基因与疾病之间的联系,但该方法所获得的相关基因较少,不利于对疾病与基因关系的全面了解. 相似文献
2.
杨平 《南京晓庄学院学报》2011,(6):80-84
运用CodonW程序对拟南芥NHX基因密码子组成、同义密码子使用频率和全长编码区密码子使用各项参数的计算和统计分析．结果表明：密码子适应指数（CAI值）与最优密码子使用频率（FOP）、密码子偏爱指数（CBI）均呈显著正相关（P〈0．05）;有效密码子数（ENC）与同义密码子第3位碱基含量（T3s）呈极显著负相关（P〈0．05）．拟南芥NHX基因RSCU值〉1的密码子多以A或T结尾． 相似文献
3.
Two ancient rounds of polyploidy in rice genome 总被引：10，自引：0，他引：10
An ancient genome duplication (PPP1) that predates divergence ofthe cereals has recently been recognized. We report here another potentially older large-scale duplication (PPP2) event that predates monocot-dicot divergence in the genome of rice(Oryza saliva L.), as inferred from the age distribution of pairs of duplicate genes based on recent genome data for rice. Our results suggest that paleopolyploidy was widespread and played an important role in the evolution of rice. 相似文献
4.
考试怯场在考生中普遍存在,不利于考生实际水平的正常发挥,严重影响考试结果。因此,我们应该积极探究考生考试怯场的生理机制、主要特征、表现形式与形成原因,并积极寻求对策加以有效预防和最优调控。 相似文献
5.
韩云妹 《宁波广播电视大学学报》2011,9(3):119-121,124
由于我国对于候选人没有资格限制、对执政党提名缺乏规范、联合提名受到种种限制等原因现在的人大代表中存在着公务员代表比例较高,导致不能实现司法权、行政权和立法权之间的分工与合作的关系,弱化人大的监督职能,使代表议事职能行政化,难以履行代表职务的时间保障。在现阶段在对候选人的职业资格不可能限制的情况下,为了降低公务员代表的比例,希望从完善候选人提名制度来解决。 相似文献
6.
SIRTUIN1介导的NIH3T3成纤维细胞昼夜节律时钟基因表达抑制的光生物调节作用 总被引：1，自引：1，他引：0
背景和目的:昼夜节律是影响运动成绩的一个重要因素。研究发现,介导运动应激的肿瘤坏死因子(tumor necrosis factor,TNF)能够抑制昼夜节律时钟基因的表达。研究了低强度810nm激光(low intensity 810 nm laserir radiation,LIL)对TNF抑制效应的调节作用。材料和方法:50%马血清休克处理NIH3T3成纤维细胞2h,同步化昼夜节律时钟基因的表达后,加入10ng/mL TNF-alpha抑制它的表达,与此同时给予20min10mW/cm2的LIL照射。36h内,每隔6h检测细胞中时钟基因Clock、Bmal1、Per2、Dbp和烟酰胺腺嘌呤二核苷酸辅酶(nicotinamide adenine dinucleotide,NAD+)依赖的组蛋白去乙酰化酶1(sirtuin1,Sirt1)的mRNA的表达及胞内NAD+和其还原形式NADH的比值NAD+/NADH。结果:TNF-alpha分别在第12h和第18h抑制了Clock(P<0.05)、第18h抑制了Bmall(P<0.05)和Dbp(P<0.005)、第18h和第30h抑制了Per2(P<0.05)及... 相似文献
7.
Aflatoxins are the most popular hepatotoxicants. Chronic exposure to aflatoxins leads to a wide variety of liver diseases, such as hepatocellular carcinoma. In this study, we analyzed the genome wide expression profiles of aflatoxin B1-induced rat hepatic epithelial cells. The expression of 325, 184 and 199 special genes was altered when exposed to 0.03, 0.1 and 0.2 μmol/L aflatoxin B1 respectively, and 239 genes were commonly expressed. After the functional analysis on these dose-special genes, we determined several key pathways related to hepatotoxicity, such as TGF-beta signaling pathway, tight junction, adherens junction, the regulation of actin cytoskeleton, Erb B signaling pathway, p53 signaling pathway, pathways in cancer and axon guidance. Common genes were mainly associated with focal adhesion, ECM-receptor interaction, and cell adhesion molecules. Gene ontology annotations showed a good concordance with these pathways. The quantitative real-time polymerase chain reaction(PCR) analysis of selected genes showed similar patterns in microarrays. The toxicogenomic study provides a better understanding of molecular mechanisms of aflatoxins. 相似文献
8.
在当今的新形势下,探索传统聚落景观基因资源与构建生态文明战略相结合的环境教育内容体系创新与实施途径具有重要的社会价值。本文结合传统聚落景观基因理论,在深入分析传统聚落景观基因所具有的环境意识特征和所体现的生态环境价值观的基础上,明确了景观基因的环境教育内涵,分析了景观基因对古代环境生态观的传承、认知与体验功能。在前述基础上,本文就实施以景观基因为特色的环境教育的基本途径做了探讨。该文的研究结果表明,将我国传统聚落所体现的生态环境特征纳入到当前的环境教育内容体系当中,是一个值得深入的课题。 相似文献
9.
Cancer is a genetic disorder.Although heredi-tary cancers account for only a small fraction of all tumors,most cancers are caused by a variable mix of heredity and environment that leads to accumulations of genetic alterations and then uncontrolled cell pro-liferations(Kops et al.,2005).In addition,genetic alteration is one of the a few most important bio-logical factors that determine the diagnosis and prognosis of different cancers and dictate the treat-ment strategies for cancer patients.Fu… 相似文献
10.
Olson RK 《Annals of dyslexia》2006,56(2):205-238
This article presents an overview of some methods and results from our continuing studies of genetic and environmental influences
on dyslexia, and on individual differences across the normal range that have been conducted over the past 25 years in the
Colorado Learning Disabilities Research Center (CLDRC) and in related projects. CLDRC investigators compare the similarities
of identical twin pairs who share all their genes and fraternal twins who share half their segregating genes to assess the
balance of genetic, shared family environment, and nonshared environment influences on dyslexia and on individual differences
across the normal range. We have learned that among the children we have studied in Colorado, group deficits in reading (dyslexia)
and individual differences in reading across the normal range are primarily due to genetic influences, and these genetic influences
are often shared with some of the same genetic influences on deficits and individual differences in language and ADHD. We
have also learned from our molecular-genetic linkage studies that there are regions on several chromosomes likely to contain
genes that influence dyslexia. Several specific genes within these regions have been tentatively identified through molecular-genetic
association analyses, but much more research is needed to understand the pathways among specific genes, regions of noncoding
DNA that regulate the activity of those genes, the brain, and dyslexia. I conclude with a discussion of our research on individual
differences in early reading development, on the role of early learning constraints in dyslexia, and on how genetic influences
are expressed through their interaction and correlation with the environment. 相似文献