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运动对GLUT4影响的研究进展   总被引:1,自引:0,他引:1  
葡萄糖跨膜转运是机体利用葡萄糖的首要步骤。葡萄糖载体(GLUT)是细胞膜上介导葡萄糖跨膜转运的蛋白质,它们对机体的葡萄糖利用有重要意义。运动可有效增加外周组织(主要为骨骼肌和脂肪组织)细胞膜葡萄糖载体4(GLUT4)的数量,使细胞内GLUT4的囊泡数量增多,GLUT4mRNA的表达增强,有效地加快血糖的转移、吸收和利用,解除外周组织胰岛素抵抗,调节血糖平衡,对糖尿病人的治疗有积极的作用和意义。  相似文献   
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简术害单糖结构推导教学中运用“磨合期”教学法的过程。  相似文献   
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INTRODUCTIONNongreenplastidsofheterotrophictissuesarecarbohydrate importingorganellesand ,inthecaseofamyloplastsofstoragetissues,thesiteofstarchsynthesis.Investigationofwholetissuesfromavarietyofstarchsynthesizingcropplantsindicatedthathexoseunitswereimpo…  相似文献   
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The present study reveals the effect of Musa paradisiaca stem juice on blood glucose level (BGL) of normal & diabetic rats. The dose of 500 mg/kg bodyweight produces a significant rise of 28.3% in blood glucose level after 6h of oral administration in normal rats. Whereas, in sub diabetic rats the same dose produces a rise of 16.4% in blood glucose levels within 1h during glucose tolerance test (GTT) and a rise of 16% after 4 h in fasting blood glucose levels of severe diabetic cases. These results were unexpected and important to report as other species of Musa like Musa sapientum has been reported for its hypoglycemic effect.  相似文献   
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目的:研究低氧条件下的冲刺训练对运动员身体内葡萄糖、胰岛素、游离脂肪酸以及乳酸应激条件下的影响.方法:所有运动员都分别参加三组不同实验条件的训练,并且每组训练相隔7天.三组不同训练条件分别为:常氧压的冲刺运动(N组);中等缺氧的冲刺运动(M组);高度缺氧的冲刺运动(H组).每组冲刺运动都在功率自行车上进行,每组运动为4次为时30s的冲刺运动,阻力都为10档,并辅以教练口头激励,每次冲刺运动后恢复6min,并记录每次运动员产生的最高功率以及平均功率.两种不同的低氧条件由低氧面具提供.训练后,分别在运动前抽取血液1次,以及在4次运动完成后5 min,30min,60min,120min各取一次,并检测各项指标.结果:1.常氧压组与两组低氧压组相比,血细胞中的葡萄糖含量没有明显的差异,但是,与没有进入运动开始前相比较,冲刺运动后的5min内葡萄糖含量上升显著.2.只有在冲刺运动完成后2h后,体内脂肪酸含量才显著上升,并且与常氧压组和中等低氧压组相比较,高度缺氧组的游离脂肪酸上升更为明显,且与这两组差异显著.3.与运动开始前相比,运动后5min、30min、60min内体内乳酸含量高,且具有显著差异.但在120min后差异消失.4.运动结束后5min时体内胰岛素含量较高,且与开始运动前和运动结束后其他三个时间段相比,具有显著差异.  相似文献   
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骨骼肌内葡糖糖的摄取和代谢对血糖稳定有重要作用。众多研究表明运动中一氧化氮(NO)大量生成对骨骼肌摄取葡糖糖有重要影响。进一步研究发现,肌肉收缩和摄取葡萄糖与NO的生成、传递联系密切,但相关机制还不明确。文章综述了运动时骨骼肌内NO及一氧化氮合酶(NOS)生成和传递的途径及其对运动中骨骼肌摄取葡糖糖的影响和可能的机制。  相似文献   
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Resistin, a newly discovered peptide hormone mainly secreted by adipose tissues, is present at high levels in serum of obese mice and may be a potential link between obesity and insulin resistance in rodents. However, some studies of rat and mouse models have associated insulin resistance and obesity with decreased resistin expression. In humans, no relationship between resistin level and insulin resistance or adiposity was observed. This suggests that additional studies are necessary to determine the specific role of resistin in the regulation of energy metabolism and adipogenesis. In the present study, we investigated the effect of resistin in vivo on glucose and lipid metabolism by over-expressing resistin in mice by intramuscular injection of a recombinant eukaryotic expression vector pcDNA3.1-Retn encoding porcine resistin gene. After injection, serum resistin and serum glucose (GLU) levels were significantly increased in the pcDNA3.1-Retn-treated mice; there was an obvious difference in total cholesterol (TC) level between the experiment and the control groups on Day 30. In pcDNA3.1-Retn-treated mice, both free fatty acid (FFA) and high density lipoprotein (HDL) cholesterol levels were markedly lower than those of control, whereas HDL cholesterol and triglyceride (TG) levels did not differ between the two groups. Furthermore, lipase activity was expressly lower on Day 20. Our data suggest that resistin over-expressed in mice might be responsible for insulin resistance and parameters related to glucose and lipid metabolism were changed accordingly.  相似文献   
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Water extract of dry fruits ofTerminalia chebula (Hindi-Harda, Telugu-Karakkaya) at a dose of 200 mg/kg body weight improved the glucose tolerance as indicated by 44% of reduction in the peak blood glucose at 2nd hour in glucose tolerance test in diabetic (streptozotocin induced) rats. Treatment of diabetic rats with an initial fasting blood glucose of 253±9.4 mg/dl daily once with the water extract (200 mg/kg) for two weeks brought down the fasting blood glucose to 123±8.4 mg/dl which is only slightly above the normal value. These results indicate that water extract of Terminalia chebula improves glucose tolerance and brings down fasting blood glucose in diabetic rats.  相似文献   
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Plastids of nongreen tissues import carbon as a source of biosynthetic pathways and energy, and glucose 6-phosphate is the preferred hexose phosphate taken up by nongreen plastids. A cDNA clone encoding glucose 6-phosphate/phosphate translocator (GPT) was isolated from a cDNA library of immature seeds of rice and named asOsGPT. The cDNA has one uninterrupted open reading frame encoding a 42 kDa polypeptide possessing transit peptide consisting of 70 amino acid residues. TheOsGPT gene maps on chromosome 8 of rice and is linked to the quantitative trait locus for 1000-grain weight. The expression ofOsGPT is mainly restricted to heterotrophic tissues. These results suggest that glucose 6-phosphate imported viaGPT can be used for starch biosynthesis in rice nongreen plastids. Project supported by National Natural Scienc Foundation of China (No.39830250) and Natural Science Foundation of Zhejiang Province (No.2A0106), China. The nucleotide sequence data will appear in the GenBank under accession number AF375053.  相似文献   
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