共查询到17条相似文献，搜索用时 828 毫秒
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[目的]探讨冷凝联合小梁切除术治疗新生血管性青光眼的疗效.[方法]A组12例14眼新生血管性青光眼,施行180°视网膜周边部巩膜外和睫状体冷凝;B组20例22眼,除上述冷凝外,又联合小梁切除术治疗.[结果]随访3～6个月,两组术后视力均无明显改善,A组平均眼压自57.48mmHg降至32mmHg,需要再做冷凝或手术减压;B组随访的15例(16眼)有14眼的眼压<21mmHg,2眼需加用0.1%噻吗心安滴眼治疗,两组术后短期内眼压控制有明显的差异(P<0.05).[结论]冷凝或联合小梁切除术对新生血管性青光眼治疗有较好的短期疗效. 相似文献
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探讨传统中药蜕皮甾酮对大鼠实验性蛛网膜下腔出血后早期脑血管痉挛的干预效应。90只SD大鼠随机分为假手术组、SAH组、EDS干预组,观察各实验组大鼠24h死亡率和神经功能缺损、局部脑血流量及形态学变化。结果表明,与假手术组比较,SAH组大鼠有明显的神经功能缺损,局部脑血流量下降,基底动脉管腔缩小,内膜皱缩呈波纹状等形态学异常、EDS干预后神经功能缺损好转,局部脑血流量在EDS干预后12h增加,形态学也有不同程度改善。蜕皮甾酮能改善大鼠实验性蛛网膜下腔出血后早期脑血管痉挛。 相似文献
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研究大鼠脑出血给予三七总皂甙治疗后,神经元Bcl-2和Bax的表达有无变化,并观察脑出血大鼠在不同时间点相干/湿重法测定脑含水量的变化.神经行为学检测结果表明,脑出血组大鼠的神经功能评分分值升高;2d后治疗组大鼠与脑出血组相比分值下降（P＜0.01）.免疫组织化学结果显示,治疗组Bcl-2的阳性表达较脑出血组高（P＜0.01）、Bax的阳性表达较脑出血组低（P＜0.01）,Bcl-2/Bax蛋白比值增高;脑含水量即12 h开始增加,24 h后比较明显,48 h达高峰,7d之后与正常组无明显差异.三七总皂甙治疗组48 h ～72h干预后,脑含水量明显低于其脑出血组（P＜0.05）. 相似文献
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《赤峰学院学报(自然科学版)》2008,(Z1)
目的:探讨CT定位下运用无框架硬通道置入技术微创穿刺治疗高血压脑出血的临床疗效。方法:将符合纳入标准和排除标准的20例高血压脑出血患者依CT片简易三维立体定位后用无框架硬通道置入技术一次性穿刺血肿靶点进行抽吸及应用生化,酶技术将血肿液化对血肿进行引流达到治疗的目的。同期符合入选标准但家属要求保守治疗20例高血压脑出血患者给予内科常规保守治疗。结果:微创穿刺治疗组较内科保守治疗组在血肿体积、GCS评分以及日常生活活动能力评价有着明显差异(P(0.01),其疗效明显优于内科保守治疗。结论:微创穿刺术是治疗高血压性脑出血的有效方法,明显降低了患者的致残率,改善了患者的预后,且损伤小,便于操作。 相似文献
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随着CT技术的应用、普及以及颅外定位准确性的提高,微创血肿粉碎穿刺术为急性高血压脑出血治疗开辟了新途径[1]。我科用微创血肿粉碎穿刺术治疗40例高血压脑出血患者,经有效的护理,取得了满意的疗效,护理体会如下。1临床资料本组患者40例,男26例,女14例,年龄40~70岁。均有高血压病史,入院时血压>140/90 mmHg,均行头颅CT检查明确诊断,多田公式计算出血量。其中基底节出血20例,≥30 mL,脑叶出血12例,≥30 mL,丘脑出血8例,≥10 mL。入院时嗜睡6例,浅昏迷10例,昏迷16例,深昏迷8例。根据CT定位选择出血最多,血肿最接近颅骨的CT层,并避开大血管及功能区。常规消毒、铺巾及麻醉,使用YL-1型颅内血肿粉碎穿刺针,向颅内血肿中心穿刺,取下针芯,缓慢抽吸,首次抽吸量控制在总量的1/3。插入冲洗针注入2万单位尿激酶,夹闭2 h后放开引流管,每日2次。根据引流量和CT结果调整穿刺针深度,待血肿清除达80%以上即可拔管[2]。本组治愈好转共32例,无效8例。2护理2.1术前护理向患者家属详细介绍穿刺原理、必要性及并发症和手术前、后的注意事项,以取得患者家属的密切配合。器械准备:YL-1型颅内血... 相似文献
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高血压性脑出血是中老年人主要致死致残疾病之一,随着老龄化人数的增多,发病率呈上升趋势。脑出血的外科治疗,以往主要是通过全麻下行开颅清除血肿术,这种手术对于基底节区主要神经结构创伤大大,且手术时间长,失血多,其病死率和病残率较高,同样内科保守治疗也得不到满意疗效。近年来,立体定向血肿清除术的临床应用,使本病的治愈率明显提高。致残率和死亡率明显降低。我院自1997a开展 相似文献
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[目的]针刺预处理对全脑缺血大鼠微血管损伤及脑水肿的保护作用.[方法]采用四动脉阻断法制作大鼠全脑缺血模型,针刺预处理组:术前给予针刺,针刺7 d后给予全脑缺血10 min,干湿法测脑组织水含量,应用HE染色、TUNEL染色及透射电镜技术,观察大鼠脑缺血后,组织病理学及超微结构改变.[结果]与脑缺血组相比,针刺预处理组不引起明显的神经元损伤,全脑缺血10 m in后72 h,微血管损伤及脑水肿明显减轻,血管内皮细胞凋亡减少.[结论]针刺预处理能够通过减轻微血管损伤及脑水肿对脑缺血产生保护作用. 相似文献
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研究了全身亚低温对缺氧缺血性脑损伤(HIBD)新生鼠脑细胞凋亡的影响.新生大鼠吸入8%O2和92%N2混合气体建立HIBD模型,33℃亚低温在HIBD后即刻开始干预6h,采用原体位末端标记技术检测脑组织中凋亡细胞数.结果表明亚低温能明显降低细胞凋亡数目,从而发挥对缺氧缺血性脑损伤的保护作用. 相似文献
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探讨内皮素(ET-1)是否参与脑出血血肿周围水肿带的形成。方法:用放射免疫分析法测定39例脑出血患者静脉血浆及颅内血肿液和正常对照组19例的静脉血浆ET-1含量。结果:脑出血患者静脉血浆ET-1含量(123.83±54.84pg/ml)显著高于对照组(30.62±6.21pg/ml),P<0.001;颅内血肿液ET-1含量(221.7 7±96.86pg/ml)显著高于静脉血浆ET-1含量,P<0.001;不同时期血浆ET-1含量(<6h者为144.86±59.82pg/ml、6～72h为128.70±50.16pg/ml、>72h为82.47±31.74pg/ml)及颅内血肿液ET-1含量(<6h者为299.03±63.72pg/ml、6～72h为231.66±53.22pg/ml、>72h为84.01±25.69pg/ml)比较,<6h含量最高,此后呈下降趋势。结论:ET-1在早期即参与了血肿周围水肿带的形成,故力争脑出血手术在超早期(<6h)进行。 相似文献
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目的：观察线栓法致大鼠局灶性脑缺血模型后,不同时相神经功能评分、脑梗死灶体积、血清神经元特异性烯醇化酶（neuron specific enolase,NSE）含量的变化.方法：大鼠随机分为脑缺血模型组和假手术组,每组大鼠又随机分为缺血1、6、12、24、72 h组与120 h组6个时相组.采用线栓法建立大鼠局灶性脑缺血模型,观察记录大鼠大脑中动脉栓塞（middle cerebral artery occlusion,MCAO）后不同时相神经功能评分、测定血清NSE含量的变化,TTC染色观察脑梗死灶体积.结果：假手术组神经功能评分均为0;模型组在缺血1h神经功能评分就明显升高,24 h达到最高,持续到120 h.假手术组脑梗死灶体积均为0;模型组在缺血6h脑梗死灶体积才明显升高,24 h达到最高,72 h明显下降,120 h再次升高.假手术组血清NSE含量在各个时相没有明显变化;模型组在缺血1h血清NSE含量就明显升高,12h达到最高,24 h明显下降,一直持续到120 h.结论：脑缺血后神经功能评分、脑梗死灶体积、血清中NSE含量都明显升高,但三者在不同时相的变化是不一致的. 相似文献
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目的：观察莫诺苷对局灶性脑缺血-再灌注大鼠细胞周期蛋白Cyclin D1及CDK6的影响。方法：用线栓法制备大鼠局灶性脑缺血-再灌注模型。将15只Sprague-Dawley（SD）大鼠随机分为假手术组,模型组,莫诺苷组（270、90、30 mg·kg-1）。利用免疫组化方法检测大鼠患侧海马Cyclin D1、CDK6表达。结果：与假手术组相比,模型组Cyclin D1及CDK6表达显著增加;给予莫诺苷治疗后,与模型组相比,莫诺苷（270、90 mg·kg-1）剂量组能显著降低大鼠Cyclin D1及CDK6的表达。结论：莫诺苷能通过降低脑缺血-再灌注后Cyclin D1及CDK6的表达而发挥神经保护作用。 相似文献
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Yun-zhen Hu Jian-wen Wang Ben-yan Luo 《Journal of Zhejiang University. Science. B》2013,14(6):496-504
Ethnicity and socioeconomic factors can influence disease susceptibility, clinical presentation, and outcome. We investigated the clinical characteristics (age, sex, seasonal variation, lesion site, symptoms, complications, prognosis, and sequelae) and risk factors for intracerebral hemorrhage (ICH) in 266 cases treated at our hospital in Hangzhou City, China, from January 2011 to December 2011. Risk of ICH increased dramatically with age; only 4.3% of cases were <30 years old, while 44.4% were >60 years of age. Men outnumbered women by 2:1 (67.3% vs. 32.7%). Single hemorrhage was most often located in the cerebral lobes (37.2% of cases), basal ganglia (34.2%), thalamus (8.3%), cerebellum (6.8%), ventricle (1.5%), and brainstem (1.1%), while 10.9% of cases exhibited hemorrhages at multiple sites. Hypertension was also a major risk factor for ICH, as 47% of all patients were hypertensive and the percentage increased with age. In hypertensive patients, the most common hemorrhage site was the basal ganglia and ICH was often associated with thrombopenia. In patients with leukemia (all forms), most hemorrhages were lobar. Warfarin- and encephalic operation-associated ICHs were all lobar. Headache was the major symptom of occipital, temporal, and frontal lobe hemorrhage. Dizziness, nausea, and vomiting were the major symptoms of cerebellum hemorrhage. Limb dysfunction was the major symptom of thalamic and basal ganglia hemorrhage. Disturbed level of consciousness was the major symptom in multisite, ventricular, parietal lobe, and brainstem hemorrhage. Hyperspasmia occurred most often in lobar hemorrhage and blurred vision in occipital lobe hemorrhage. Hospital mortality was 24.4% (n=65) with a mean delay from presentation to death of (10.5±18.5) d. The majority of fatalities were cerebral hernia cases (58.5%) and these patients also had the shortest time to death [(2.9±3.5) d]. Mortality was 100% in brainstem ICH and hemorrhagic conversion of cerebral infarct. Thrombopenia-associated ICH also had a high mortality rate (81.0%), while patients with cerebrovascular malformations and cerebral aneurysms demonstrated a much better prognosis (46.2% recovery). 相似文献
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Study of clinical features of amyloid angiopathy hemorrhage and hypertensive intracerebral hemorrhage 总被引：3，自引：0，他引：3
詹仁雅 童鹰 沈剑峰 LANG E. PREUL C. HEMPELMANN R.G. HUGO H.H. BUHL R. BARTH H. KLINGE H. MEHDORN H.M 《Journal of Zhejiang University. Science. B》2004,(10)
Objective: The purpose of this study was to differentiate between cerebral amyloid angiopathy (CAA) and hypertension (HTN) based on hemorrhage pattern interpretation. Methods: From June 1994 to Oct., 2000, 83 patients admitted to our service with acute intracerebral hemorrhage (ICH) were investigated retrospectively; 41 patients with his-tologically proven diagnosis of cerebral amyloid angiography and 42 patients with clear history of hypertension were investigated. Results: Patients with a CAA-related ICH were significantly older than patients with a HTN-related ICH (74.0 years vs 66.5 years, P<0.05). There was a significantly higher number of hematomas>30 ml in CAA (85.3%) when compared with HTN (59.5%). No basal ganglional hemorrhage was seen in CAA, but in 40.5% in HTN. In CAA-related ICH, su-barachnoid hemorrhage (SAH) was seen in 26 patients (63.4%) compared to only 11 patients (26.2%) in HTN-related ICH. Intraventricular hemorrhage was seen in 24.4% in CAA, and in 26.2% in HTN. Typical features o 相似文献
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Objective: The purpose of this study was to differentiate between cerebral amyloid angiopathy (CAA) and hypertension (HTN) based on hemorrhage pattern interpretation. Methods: From June 1994 to Oct., 2000, 83 patients admitted to our service with acute intracerebral hemorrhage (ICH) were investigated retrospectively; 41 patients with histologically proven diagnosis of cerebral amyloid angiography and 42 patients with clear history of hypertension were investigated. Results: Patients with a CAA-related ICH were significantly older than patients with a HTN-related ICH (74.0years vs 66.5 years, P＜0.05). There was a significantly higher number ofhematomas≥30 ml in CAA (85.3%) when compared with HTN (59.5%). No basal ganglional hemorrhage was seen in CAA, but in 40.5% in HTN. In CAA-related ICH, subarachnoid hemorrhage (SAH) was seen in 26 patients (63.4%) compared to only 11 patients (26.2%) in HTN-related ICH.Intraventricular hemorrhage was seen in 24.4% in CAA, and in 26.2% in HTN. Typical features of CAA-related ICH included lobar distribution affecting mainly the lobar superficial areas, lobulated appearance, rupture into the subarachnoid space, and secondary IVH from the lobar hemorrhage. More specifically, multiplicity of hemorrhage, bilaterality, and repeated episodes also strongly suggest the diagnosis of CAA. Multiple hemorrhages, defined as 2 or more separate hematomas in multiple lobes, accounted for 17.1% in CAA-related ICH. Conclusion: There are certain features in CAA on CT and MRI and in clinical settings. To some extent, these features may contribute to distinguishing CAA from HTN related ICH. 相似文献
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目的观察乙醇对大鼠大脑皮层和纹状体细胞内Ca^2＋的影响。方法 雄性Wistar大鼠30只,随机分为对照组,乙醇灌胃后0．5h组,1．5h组,3h组和、5h组（各6只）。实验组用60％（V／V）白酒一次性灌胃（灌胃体积为10ml／kg）,对照组用等体积生理盐水灌胃。在各时间点急性分离大脑皮层和纹状体细胞,用Ca^2＋敏感荧光指示剂Fluo-3／AM负载,共聚焦显微镜测定细胞内游离Ca^2＋结果。染毒后大鼠大脑皮层和纹状体细胞内游离Ca^2＋荧光强度均降低（与对照组比较）,其中,1．5h组降低有显著差异（P〈0．01,P〈0.05）。结论乙醇产生神经行为毒性可能与大脑皮层和纹状体细胞内Ca^2＋尝试降低有关。 相似文献