共查询到18条相似文献，搜索用时 406 毫秒
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固有无序蛋白是一类具有柔性结构的蛋白质,许多情况下通过与其它物质相互作用形成稳定结构来发挥重要生物功能.本文分别利用基于序列特征和结构特征的蛋白质结合位点预测程序对固有无序蛋白有序区和无序区与核酸分子的结合位点进行了预测分析.结果发现,基于结构特征的结合位点预测方法整体上要优于基于序列特征的预测方法,表明无序区尽管缺少稳定空间结构,结构特征依然在固有无序蛋白结合位点中发挥了重要作用.因此,可以为今后固有无序蛋白序列特征及结构特征的提取提供可靠依据. 相似文献
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固有无序蛋白质是一种新的蛋白质类型,具有显著的序列结构特征,尤其在与DNA相互作用中发挥着重要功能.分别统计分析了固有无序蛋白质有序区和无序区与DNA形成的复合物中,位于结合位点处脱氧核苷酸的结合偏好性以及与氨基酸组成结合对的偏好性.结果发现,参与这种相互作用的脱氧核苷酸类型具有显著差异,其中鸟嘌呤脱氧核苷酸和胸腺嘧啶脱氧核苷酸较受欢迎,而腺嘌呤脱氧核苷酸和胞嘧啶脱氧核苷酸不受欢迎.我们还发现四种脱氧核苷酸都偏好与精氨酸和赖氨酸组成结合对,而很少与天冬氨酸和谷氨酸结合.因此,本文将为今后DNA与其它分子相互作用研究提供可靠的数据和方法支持. 相似文献
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植物抗病因子是近年来生物学上的研究热点,本文较为详细地介绍了病原相关蛋白的发现、类型、性质、结构、生物学功能、分布以及在植物抗病中的作用,为深入进行这类蛋白的研究提供了参考。 相似文献
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自上世纪60年代证实早在19世纪末从蓖麻中分离的第一个毒蛋白--蓖麻毒蛋白(ricin)具有抑制蛋白质生物合成作用以来,经过几十年研究表明核糖体失活蛋白(Ribosome inactivating proteins,RIPs)是一类在植物界中广泛存在的毒蛋白.它可以对哺乳动物核糖体的28srRNA进行脱腺嘌呤作用,破坏核糖体的功能,从而抑制蛋白质的生物合成.除了能使蛋白质合成受阻外,RIP还具有抗生育、抗肿瘤和抗艾滋病病毒等诸多生物活性.RIP这种对人类及动物细胞的独特作用,现已成为研究细胞生物学的重要工具,并在临床抗肿瘤和抗艾滋病等病毒治疗上的潜在研究和应用价值.因此引起了人们利用核糖体失活蛋白进行药物的开发以及在生物工程的应用的极大兴趣. 相似文献
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硒蛋白及其生物学功能 总被引：5，自引：0，他引：5
硒蛋白是人及动物必需微量元素硒的主要功能形式。近年对硒蛋白的研究取得了诸多进展，例如，发现了在细胞增殖过程中具重要作用的硒蛋白硫氧还蛋白还原酶；深人研究了硒蛋白 P 的结构、表达调控、生物学功能等；揭示了硒以硒半胱氨酸形式参与构成酶的活性中心，而硒半胱氨酸本身则为生物合成和参入到蛋白质中的第21种氨基酸；在哺乳动物发现的35种硒蛋白中．已有十几种研究得比较清楚。本文就这些硒蛋白的结构、分布等特点及生物学功能方面的研究现状作一简要综述。 相似文献
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热激蛋白是一类在生物体受到逆境胁迫后大量表达的蛋白质。其功能主要涉及蛋白质的重新折叠、稳定、组装、胞内运输和降解以及对受损蛋白质的修复等。本文综述了植物热激蛋白的诱导合成、种类和结构、胁迫条件下的生物学功能、基因表达调控方面的研究进展。 相似文献
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<正>1.教学分析1.1本节课在高中生物学教学中的地位"生命活动的主要承担者—蛋白质"一节是人教版高中生物必修一《分子与细胞》第二章第2节的内容。内容抽象,难点较多,其中的相关知识涉及高中生物学全部教材。如必修一中酶的知识涉及蛋白质的催化功能,载体蛋白、血红蛋白等涉及蛋白质的运输功能;必修二中染色体的相关知识将遗传信息的携带者与生命活动的承担者联系起来;必修三和调节有关的物质如激素、抗体等又涉及蛋白质的信息传递及免疫功能。可见本 相似文献
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内质网是体内蛋白质产生和质量控制的关键场所,体内约1/3的蛋白是经内质网合成并加工发挥作用。蛋白质合成后需要进行一定的折叠,形成正确的三维构象,从而发挥其功能。然而在蛋白质折叠过程中易出现错误,导致未折叠和（或）错误折叠蛋白在内质网内聚集,进而导致内质网应激。对此,机体可通过内质网质量控制（ERQC）和内质网相关降解（ERAD）对生成的蛋白质质量进行检测,并通过降解异常折叠蛋白质,以维持内质网内蛋白稳态。目前为止,对哺乳动物体内有关蛋白质折叠和ERAD的详细机制描述尚不全面。为此,本文综述了哺乳动物细胞中蛋白质折叠与ERAD的过程和功能,并重点对ERAD相关蛋白质构象疾病的潜在病理生理学进行了介绍。 相似文献
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黄晶 《温州职业技术学院学报》2014,(1):51-53,73
中小物流企业对促进区域经济发展发挥着重要作用.当前中小物流企业与区域经济发展存在政府政策支持不够、基础设施缺乏规划、企业竞争无序等诸多问题.为此,政府应规划物流发展,加强中小物流企业与工商企业联动发展,建立物流行业协会,搭建物流信息共享平台,使中小物流企业与区域经济协调发展. 相似文献
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OBJECTIVE: Although many studies have identified associations between childhood maltreatment and later substance use and disordered eating, few have examined causal or explanatory pathways, and whether victim characteristics predict the development of one versus the other of these outcomes remains uninvestigated. Furthermore, relatively little childhood maltreatment research has examined Latino samples. To address these gaps, this study examined among Latina adolescents the effects of sexual abuse, physical/emotional abuse, neglect, disconnection from family, and parental alcohol problems on poly-substance use and disordered eating, and whether five individual characteristics explain or differentiate these outcomes. METHOD: Data from a community sample of 361 Latina adolescents were analyzed using structural equation modeling. RESULTS: Physical/emotional abuse predicted poly-substance use and weight concerns, and these associations were mediated by impaired current attachment. Disconnection from family predicted bulimic behaviors, and this association was mediated by dysphoria. One indirect path also emerged: Disconnection from family predicted low social conformity, and low social conformity predicted poly-substance use. Childhood sexual abuse did not uniquely predict any adverse outcome or individual characteristic examined. CONCLUSIONS: Dysphoria and impaired current attachment appear to play important roles in the development of substance use and disordered eating in Latina adolescents when physical/emotional abuse or disconnection from family predicts these outcomes. Dysphoria and low social conformity may differentiate the development of bulimic behaviors and poly-substance use, respectively, when family disconnection predicts these outcomes. 相似文献
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Adenosine diphosphate(ADP)-ribosylation is a unique post-translational modification that regulates many biological processes,such as DNA damage repair.During DNA repair,ADP-ribosylation needs to be reversed by ADP-ribosylhydrolases.A group of ADP-ribosylhydrolases have a catalytic domain,namely the macrodomain,which is conserved in evolution from prokaryotes to humans.Not all macrodomains remove ADP-ribosylation.One set of macrodomains loses enzymatic activity and only binds to ADP-ribose(ADPR).Here,we summarize the biological functions of these macrodomains in DNA damage repair and compare the structure of enzymatically active and inactive macrodomains.Moreover,small molecular inhibitors have been developed that target macrodomains to suppress DNA damage repair and tumor growth.Macrodomain proteins are also expressed in pathogens,such as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).However,these domains may not be directly involved in DNA damage repair in the hosts or pathogens.Instead,they play key roles in pathogen replication.Thus,by targeting macrodomains it may be possible to treat pathogen-induced diseases,such as coronavirus disease 2019(COVID-19). 相似文献
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This paper analyzes the debates on “interracial competition” and “racial extinction” in the biological discourse on human
evolution during the second half of the nineteenth century. Our intention is to discuss the ideological function of these
biological concepts as tools for the naturalization and scientific legitimation of racial hierarchies during that period.
We argue that the examination of these scientific discussions about race from a historical perspective can play the role of
a critical platform for students and teachers to think about the role of science in current othering processes, such as those
related to biomedical technosciences. If they learn how biological ideas played an ideological function concerning interracial
relationships in the past, they can be compelled to ask which ideological functions the biological knowledge they are teaching
and learning might play now. If this is properly balanced, they can eventually both value scientific knowledge for its contributions
and have a critical appraisal of some of its implications. We propose, here, a number of initial design principles for the
construction of teaching sequences about scientific racism and science-technology-society relationships, yet to be empirically
tested by iterative cycles of implementation in basic education and teacher education classrooms. 相似文献
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学业评价模式的初步研究 总被引：1，自引：0，他引：1
学业评价模式是评价理论与评价实践的中介，它具有构建理论与指导实践的两重功能。作为一种重要的评价研究方法，学业评价的模式化研究对于改变当前学业评价研究的无序状态，使之逐步走向理论化、系统化、结构化，将发挥重要作用。 相似文献
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以制作、交易、播出为主要环节的电视剧产业链基本形成。电视剧市场的交易环节已经成为连接电视剧产业的枢纽。研究电视剧市场交易环节,可以发现存在许多问题,主要表现在版权问题突出、价格体系混乱、交易支付欠佳等方面。追根溯源,电视剧市场交易过程出现的重重问题,与电视剧产业管理体制、市场运作机制、市场交易观念有密切关系。 相似文献
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取代硝基芳烃生物毒性与结构的相关性 总被引：1，自引：0，他引：1
李宝宗 《商丘师范学院学报》2004,20(5):113-114,134
采用半经验量子化学AMl方法和分子图形学技术，获得24种取代硝基芳烃的电子结构和立体结构参数，并将这些参数与取代硝基芳烃对斜生栅列藻的生物毒性相关联．结果表明，取代硝基芳烃的斜生栅列藻生物毒性与最低空轨道能(ELUMO)、最小立体差异(MSD)两种参数相关性较好，成功地建立了取代硝基芳烃的构效关系方程式．找出了影响取代硝基芳烃的斜生栅列藻生物毒性的主要结构因素． 相似文献
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GILLIAN L. S. Hilton 《Gender and education》1991,3(3):311-313
This article discusses the attitudes of people concerned with the under fives, to the subject of gender and play experiences. Playgroup workers, parents and social work staff were questioned on their beliefs about children's choices in play. Amongst the playgroup workers and social work staff there appeared to be a belief that children should be free to choose their play activities and that these choices were often influenced by gender, as biological factors make boys and girls want to play in different ways. Parents, they believed, would object to any coercion or positive discrimination in favour of girls to allow them equal access to play material. Parents, on the other hand, were anxious for playgroups to remove gender stereotyping and assumed that positive action was being taken. There appears to be a serious lack of communication between these groups. 相似文献