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1.
参麦注射液对急性心肌梗死大鼠心室重构的影响 总被引：3，自引：0，他引：3
目的：探讨参麦注射液对急性心肌梗死（AMI）大鼠心室重构的影响。方法：通过结扎冠状动脉前降支建立AMI模型大鼠，AMI后24h存活的48只大鼠随机分为四组：AMI后1周模型组；AMI后参麦注射液治疗1周组；AMI后2周模型组；AMI后参麦注射液治疗2周组。另设1周、2周假手术组各8只。治疗组每日腹腔注射参麦注射液1次，AMI模型组和假手术组大鼠腹腔注射等量的生理盐水。测量各组心室重构参数。结果：与假手术组比较，AMI后1周时，心室腔已明显扩大（P〈0．05）；到梗死后2周时，心室腔内径扩大更明显，与假手术组相比有显著性差异（P〈0．01），且心室重量指数（VWI）比假手术组明显增加（P〈0．05）。参麦注射液治疗2周后可改善心梗后心室重量指数增加、心室腔扩大的病理变化（P〈0．05）。结论：参麦注射液能改善大鼠AMI后心室重构。 相似文献
2.
目的：探讨藻酸双脂钠（PSS）治疗急性脑梗死患者血液成分变化及疗效。方法：急性脑梗死患者158例，随机分为两组。对照组：78例，常规治疗；治疗组：80例，在常规治疗基础上，应用藻酸双脂钠注射液100mg加入0．9％氯化钠静脉滴注，每日一次，连续观察14d。对比分析二组治疗前后脂蛋白（a）、血脂、纤维蛋白原等血液流变学指标．并动态观察治疗前后临床神经功能缺损评分。结果：藻酸双脂钠可降低全血粘度、血浆粘度、血小板聚集率、纤维蛋白原及血清TC、TG、LDL，与治疗前比较有显著性改变（P〈0．01或P〈0．05）；与对照组比较有显著性差异（P〈0．01或P〈0．05）．但对脂蛋白（a）无影响；近期预后较常规治疗组好（P〈0．05）．结论：藻酸双脂钠可改善血液高粘滞状态，起到降低纤维蛋白原、抗血小板聚集作用，可改善近期临床神经功能缺损程度。 相似文献
3.
目的：观察奥扎格雷钠与黄芪注射液联合治疗糖尿病肾病的疗效。方法：将84例早期糖尿病肾病患者随机分为3组，每组28例，在常规治疗的基础上，A组加用黄芪注射液，B组加用奥扎格雷钠注射液，C组加用黄芪注射液与奥扎格雷钠注射液，疗程均为20d。观察治疗前后各组尿白蛋白排泄率（UAER），血尿素氮（BUN），血清肌酐（SCr），糖化血红蛋白（HbAlc）的变化。结果：糖化血红蛋白，血清肌酐，血尿素氮，尿白蛋白排泄取：3组治疗后均比治疗前显著下降（P〈0．01），C组下降幅度优于A组和B组（P〈0．05）。结论：奥扎格雷钠联合黄芪注射液治疗糖尿病肾病能降低糖化血红蛋白，显著降低尿白蛋白排泄率，同时改善肾功能。 相似文献
4.
目的：探讨急慢性乙醇中毒对大鼠心脏的影响机制．方法：雄性健康SD大鼠,随机分为急性和慢性对照组、急性和慢性乙醇中毒组,每组8只．酶法和比色法检测血清和心肌组织谷草转氨酶（AST）、肌酸磷酸激酶（CPK）、超氧化物歧化酶（SOD）、丙二醛（MDA）、Ca^2＋-Mg^2＋-ATPase和Na^2＋-K^＋-ATPase的含量,观察心肌微细结构的改变．结果：与对照组相比：急、慢性乙醇中毒＋组心肌MDA、AST、CPK和血清AST、CPK含量升高（P〈0．05,P〈0．01）,SOD含量减少（P〈0．05,P〈0．01）,Na^2＋-K^＋-ATPase和Ca^2＋-Mg^＋-ATPase活性降低（P〈0．05,P〈0．01）．心肌组织HE染色显示,乙醇中毒组大鼠心肌细胞肿胀、细胞界限模糊不清,慢性组尤为明显．结论：急慢性乙醇中毒通过对大鼠心肌酶和氧自由基的影响而对心脏产生抑制作用． 相似文献
5.
贾静 《河北北方学院学报(医学版)》2010,27(4):30-31
目的：观察中西医结合治疗激素依赖型肾病综合征的疗效。方法：将53例患者随机分为治疗组30例,对照组23例。对照组给予激素及细胞毒药物常规治疗。治疗组在对照组的基础上加用补脾益肾、活血化瘀中药加减。观察两组24h尿蛋白定量,尿FDP及血清白蛋白变化。结果：治疗组疗效优于单纯用西药的对照组（P〈0．05）,且两组治疗后24h尿蛋白、尿FDP,血清白蛋白指标差异均有显著性（P〈0．001）。治疗组治疗前后血、尿生化指标差异均有显著性（P〈0．001）。结论：采用中西医结合治疗激素依赖型肾病综合征,其多项生化指标及疗效要明显优于单纯西药治疗,并且能够明显改善西药治疗的副作用,值得在临床上推广使用。 相似文献
6.
缪小莉 《泰州职业技术学院学报》2010,10(3):34-35,59
目的观察血必净注射液在治疗急性有机磷农药中毒时的疗效。方法将82例急性有机磷农药中毒患者随机分为血必净治疗组（40例）与对照组（42例）,在正规使用阿托品及胆碱酯酶复能剂治疗的基础上,治疗组加用血必净100ml静脉点滴,每天一次,共3天,50ml静脉点滴,每天一次,共4天,总疗程一周。观察治疗过程中两组间全血胆碱酯酶及C反应蛋白差别,统计平均住院时间及死亡率。结果治疗前后,血必净治疗组及对照组的全血胆碱酯酶均有恢复,且治疗组较对照组恢复速度快（P〈O．05）。在C反应蛋白水平治疗后第3、4天数值较前均有所改善（P〈0．05）,治疗组改善更著（P〈O．05）。治疗组平均住院时间明显少于对照组（P〈O．05）。结论血必净注射液能有效促进血胆碱酯酶恢复,较好调控机体炎症反应过程,改善SIRS症状,缩短住院时间,取得满意的疗效。 相似文献
7.
复方中药提高荷EAC鼠NK细胞功能介导抑瘤作用 总被引：1，自引：0，他引：1
[目的]探讨复方中药对EAC荷瘤小鼠的免疫功能的影响。[方法]用复方中药（FFZY）对EAC荷瘤小鼠灌胃10d，观察其肿瘤生长情况以及用乳酸脱氢酶释放法检测NK细胞的活性。[结果]高、中和低浓度组NK细胞活性分别为（44．21±3．10）％、（51．09±4．94）％和（37．30±2．02）％，与空白对照组（31．26±2．79）％比较，NK细胞活性升高（P〈0．05），而阴性对照组（26．90±1．84）％NK细胞活性显著降低（P〈0．05）；高、中和低浓度组的肿瘤质量为（300．6±48．9）mg，（226．5±36．4）mg和（445．9±60．2）mg，与阴性对照组（661．5±102．8）mg比较，均能抑制肿瘤的生长（P〈0．05），其中以中浓度组效果最为明显（P〈0．05）。[结论]经过复方中药灌冒的EAC荷瘤小鼠NK细胞活件均升高．3种不同浓度的复方中药均使肿瘤生长减慢。 相似文献
8.
目的：探讨在监测血清脑钠肽水平下,短期使用注射用重组人脑利钠肽治疗急性心力衰竭或慢性心力衰竭急性发作的临床效果。方法：48例急性心力衰竭患者根据是否使用注射用重组人脑利钠肽分为常规组和注射用重组人脑利钠肽组,对比两组治疗的临床效果和超声心动图情况,并监测BNP水平。结果：治疗7d后,注射用重组人脑利钠肽组临床有效率明显好于常规组（81．7％vs61．6％,P〈0．05）,左室射血分数明显高于常规组（51±6）％vs（46±5）％,（P〈0．01）,且血清脑钠肽水平明显降低（498±209）pg／mL vs（642±318）pg／mL,（P〈0．01）,血清脑钠肽下降水平和左室射血分数提高水平差异有统计学意义（P〈0．05）,有效者治疗后左室射血分数提高及血清脑钠肽下降均强于无效者（P〈0．01）。结论：在血清脑钠肽指导下短期应用注射用重组人脑利钠肽有助于改善急性心力衰竭患者的临床症状和心功能。 相似文献
9.
以凡纳滨对虾为研究对象,让其暴露在含0,5,15,45,135μg/L辛基酚（OP）的养殖水体中,暴露24,48,72,96,120 h后取样,分析测定凡纳滨对虾壳膜与内脏 NAGase 比活力的变化．结果表明,水体 OP 对对虾壳膜 NAGase比活力基本起激活作用．暴露72 h内,壳膜 NAGase比活力无显著性变化;暴露96 h时,5,15,135μg/L OP均对虾壳膜 NAGase 比活力起极显著激活作用（P＜0．01）,45μg/L OP 对虾壳膜 NAGase比活力起显著激活（P＜0．05）;暴露120 h时,15,135μg/L OP 对虾壳膜 NAGase 比活力仍表现为显著性激活作用（P＜0．05）,但5,45μg/L OP 对壳膜 NAGase 的比活力影响无显著性．而水体 OP 对虾内脏 NAGase比活力基本起抑制作用．在15μg/L OP体系下暴露24 h,内脏NAGase极显著下降（P＜0．01）,其他 OP浓度下无显著性变化;不同浓度下暴露48 h,对虾内脏 NAGase比活力均出现极显著下降（P＜0．01）;5μg/L OP体系下暴露72 h,对虾内脏 NAGase比活力无显著性下降,其他 OP 浓度下的对虾内脏 NAGase 比活力均出现极显著下降（P＜0．01）;15,135μg/L OP 体系下暴露96 h,内脏 NAGase 比活力也分别出现极显著（P＜0．01）及显著性（P＜0．05）下降．可见,OP暴露对对虾生长发育会产生影响． 相似文献
10.
张丽红 《赤峰学院学报(自然科学版)》2012,(1):59-60
目的：探讨布地奈德雾化吸入治疗115例小儿急性喉炎的示效。方法：回顾性分析：2008年1月-2011年5月就诊115例急性喉炎的患儿随机分为观察组（59例）和对照组（56例）采用氧气驱动雾化吸入,观察组为布地奈德首次1毫升（含普米克0．5mg）＋生理盐水2毫升,对照组为地塞米松每次2mg＋生理盐水2毫升。结果：观察组和对照组间的总有效率比较差异,无统计学意义（p〉0．05）观察组显效达到75．36％,显著高于对照组（56．06％）差异统计学意义（P〈0．05）;观察组平均住院时间为3．5天,显著高于对照组（5．4天）差异有统计意义（P〈0．05）。结论：氧气驱动雾化吸入布地奈德在治疗小儿急性喉炎时效果低于地塞米松且不良反应少值得临床推广。 相似文献
11.
Xin-bo Wu Guo-xin Fan Xin Gu Tu-gang Shen Xiao-fei Guan An-nan Hu Hai-long Zhang Shi-sheng He 《Journal of Zhejiang University. Science. B》2016,17(7):553-560
Objectives
This study aimed to compare the learning curves of percutaneous endoscopic lumbar discectomy (PELD) in a transforaminal approach at the L4/5 and L5/S1 levels.Methods
We retrospectively reviewed the first 60 cases at the L4/5 level (Group I) and the first 60 cases at the L5/S1 level (Group II) of PELD performed by one spine surgeon. The patients were divided into subgroups A, B, and C (Group I: A cases 1–20, B cases 21–40, C cases 41–60; Group II: A cases 1–20, B cases 21–40, C cases 41–60). Operation time was thoroughly analyzed.Results
Compared with the L4/5 level, the learning curve of transforaminal PELD at the L5/S1 level was flatter. The mean operation times of Groups IA, IB, and IC were (88.75±17.02), (67.75±6.16), and (64.85±7.82) min, respectively. There was a significant difference between Groups A and B (P<0.05), but no significant difference between Groups B and C (P=0.20). The mean operation times of Groups IIA, IIB, and IIC were (117.25±13.62), (109.50±11.20), and (92.15±11.94) min, respectively. There was no significant difference between Groups A and B (P=0.06), but there was a significant difference between Groups B and C (P<0.05). There were 6 cases of postoperative dysesthesia (POD) in Group I and 2 cases in Group IIA (P=0.27). There were 2 cases of residual disc in Group I, and 4 cases in Group II (P=0.67). There were 3 cases of recurrence in Group I, and 2 cases in Group II (P>0.05).Conclusions
Compared with the L5/S1 level, the learning curve of PELD in a transforaminal approach at the L4/5 level was steeper, suggesting that the L4/5 level might be easier to master after short-term professional training.12.
顾颖 《泰州职业技术学院学报》2001,1(1):41-43
该对113例胸腔液患给予胸腔置管引流灌入匹服平治疗（B组），并与不抽胸水灌注匹服平（A组）及胸腔置管引流后灌注榄香烯乳（C组），其CR％分别为A组21．2％，B组47．6％，C组23．7％，B组与A组及B组与C组比较均有显性差异（P＜0．05），说明胸腔置管引流后灌注匹服平治疗恶性胸水能获得较满意疗效。 相似文献
13.
Rats received pairings of two stimuli with reward noncontingently in the Skinner box. During noncontingent pairings, the bar was immobilized. For Group CC 100% of the presentations of both stimuli were rewarded (S1 ±, S2 ±), for Group PP 50% of the presentations of each stimulus were rewarded (S1, ±, S2±), and for Group PC one stimulus was followed by reward on 50% of its presentations, while the second stimulus was followed by reward on 100% of its presentations (S1 ±, S2 ±). A fourth group received the stimuli and reward nonpaired. In a subsequent rewarded test phase, the response facilitating effects of the stimuli were evaluated. In the test phase all groups that received reward paired with S1, and S2 performed better in the presence of S1 and S2 than the group for which the stimuli were not paired with reward. For groups that received the stimuli paired with reward, a difference due to schedule of reward occurred when schedule of reward was varied within Ss (Group PC), but not when varied between Ss (Group PP vs Group CC). The specific form of this finding was that Group PC’s performance in the presence of S2 ± was more vigorous than its performance in the presence of S1 ± and was more vigorous than the performance of Groups PP and CC to S2. Group PC’s performance to S1 ± did not differ from that of Groups PP and CC to S1. 相似文献
14.
Fang LIU Min WU Yan-huan FENG Hui ZHONG Tian-lei CUI You-qun HUANG Ya-ping LIANG Yong-shu DIAO Li ZANG Ling LI Jing ZANG Hong-yu QIU Song-min HUANG Ping FU 《Journal of Zhejiang University. Science. B》2013,14(11):1033-1040
The aim of this study was to understand the characteristics of blood pressure(BP)variability in subjects with diabetic nephropathy(DN),and identify the probable predictors affecting BP variability.Fifty-one chronic kidney disease(CKD)-hypertensive patients without diabetes(NDN group)and sixty type 2 diabetic patients with overt DN(DN group)were enrolled in this study.The values of short-term BP variability were obtained from 24 h ambulatory BP monitoring(ABPM).Variance analysis or nonparametric analysis revealed that 24-h systolic BP variability and nighttime systolic BP variability of the DN group were significantly higher than those of the NDN group[(12.23±3.66)vs.(10.74±3.83)mmHg,P<0.05;(11.23±4.82)vs.(9.48±3.69)mmHg,P<0.05].Then the patients of the DN group were divided into two groups according to glycated hemoglobin(HbA1c)level:Group A(HbA1c<7%)and Group B(HbA1c≥7%),and the t-test showed that patients in Group B had larger 24-h diastolic,daytime diastolic,and nighttime systolic/diastolic BP variability compared with Group A.In the DN group,partial correlation analysis revealed that HbA1c exhibited a strong association with 24-h diastolic,daytime diastolic,nighttime systolic and diastolic BP variability(P<0.001,P<0.001,P<0.05,and P<0.001,respectively).Taken together,larger short-term BP variability was detected in hypertensive type 2 diabetic patients with overt nephropathy and renal insufficiency.It may imply that the optimal BP variability level could benefit from a better glycaemic control. 相似文献
15.
Use and effects of liver specific antigen in orthotopic liver transplantations were researched in this study. Group I: syngeneic
control (Wistar-to-Wistar); Group II: acute rejection (SD-to-Wistar); Group III: Thymic inoculation of SD rat LSA day 7 before
transplantation. The observation of common situation and survival time, rejection grades, NF-κB activity of splenocytes and
IL-2mRNA expression of grafted liver were used to analyze acute rejection severity and immune state of animals in different
groups. The common situation of group I was very well after transplantation and no signs of rejection were found. Recipients
of group II lost body weight progressively All dead within day 9 to day 13 posttransplantation; median survival time was 10.7
±0.51 days. It was an optimal acute rejection control. As for group III, 5 out of 6 recipients survived for a long time and
common situation was remarkably better than that of group II. Its rejection grades were significantly lower than that of group
II(P<0.05). NF-κB activity was only detected in group I at day 5 and day 7 after transplantation, whereas high activity of NF-κB
was detected at all time points in groupII and the low NF-κB activity detected in group III was significantly lower than that
of group II (P<0.05). No IL-2mRNA expression was detected at any time point in group I, whereas high level expression was detected at all
time points in group II and the low level expression only detected at day 3 in group III was significantly lower than that
of group II (P<0.05). Conclusion: LSA is an important transplantation antigen which is involved directly in the immunorejection of liver
transplantation. We report here for the first time that intrathymic inoculation of LSA can alleviate the rejection of liver
allotransplantation; and that grafts can survive for a long time thereby, thus leading to a novel way to achieve liver transplantation
immunotolerance.
Project (NO. 011106206) supported by the Science and Technology Bureau of Zhejiang Province Foundation 相似文献
16.
目的 :观察中药方剂 (自拟降糖汤 )对控制糖尿病病情的治疗效果 .方法 :6 3例糖尿病患者分成A、B两组 .A组在常规治疗基础上加用降糖汤 ,B组予以常规治疗 ,不加降糖汤 .结果 :A组治疗后空腹及餐后 2小时血糖均明显下降 ,差异具有显著性 (P <0 0 5 ) .B组治疗前后空腹及餐后 2小时血糖无明显变化 ,差异无显著性 (P >0 0 5 ) .结论 :降糖汤对控制糖尿病患者血糖确有一定疗效 相似文献
17.
INTRODUCTION Telomeres are distinctive DNA-protein struc-tures that cap the ends of linear chromosomes.It is very important to keep the chromosomes stabilization.Telomerase activity is closely linked to attainment of cellular immortality,a step in carcinogenesis,while lack of such activity contributes to cellular senes-cence.Telomerase is activated in more than85%ofmalignant tumors(Hiayma et al.,1997).Human te-lomeric repeat binding factor1(TRF1)is a telomere associated with proteins a… 相似文献
18.
Jun-xian CAO Lu FU Qian-ping GAO Rong-sheng XIE Fan QU 《Journal of Zhejiang University. Science. B》2014,15(6):515-521
Objective
To investigate stretch-induced electrophysiological changes in chronically infarcted hearts and the effect of streptomycin (SM) on these changes in vivo.Methods
Sixty Wistar rats were divided randomly into four groups: a control group (n=15), an SM group (n=15), a myocardial infarction (MI) group (n=15), and an MI+SM group (n=15). Chronic MI was obtained by ligating the left anterior descending branch (LAD) of rat hearts for eight weeks. The in vivo blockade of stretch-activated ion channels (SACs) was achieved by intramuscular injection of SM (180 mg/(kg·d)) for seven days after operation. The hearts were stretched for 5 s by occlusion of the aortic arch. Suction electrodes were placed on the anterior wall of left ventricle to record the monophasic action potential (MAP). The effect of stretching was examined by assessing the 90% monophasic action potential duration (MAPD90), premature ventricular beats (PVBs), and ventricular tachycardia (VT).Results
The MAPD90 decreased during stretching in both the control (from (50.27±5.61) ms to (46.27±4.51) ms, P<0.05) and MI groups (from (65.47±6.38) ms to (57.47±5.76 ms), P<0.01). SM inhibited the decrease in MAPD90 during inflation ((46.27±4.51) ms vs. (49.53±3.52) ms, P<0.05 in normal hearts; (57.47±5.76) ms vs. (61.87±5.33) ms, P<0.05 in MI hearts). The occurrence of PVBs and VT in the MI group increased compared with that in the control group (PVB: 7.93±1.66 vs. 1.80±0.86, P<0.01; VT: 7 vs. 1, P<0.05). SM decreased the occurrence of PVBs in both normal and MI hearts (0.93±0.59 vs. 1.80±0.86 in normal hearts, P<0.05; 5.40±1.18 vs. 7.93±1.66 in MI hearts, P<0.01).Conclusions
Stretch-induced MAPD90 changes and arrhythmias were observed in chronically infarcted myocardium. The use of SM in vivo decreased the incidence of PVBs but not of VT. This suggests that SACs may be involved in mechanoelectric feedback (MEF), but that there might be other mechanisms involved in causing VT in chronic MI. 相似文献19.
Objectives: To directly compare the quality of harmonic imaging (HI) and fundamental imaging (FI) in fetal echocardiography and to determine any differences in image quality between the two modalities. Methods: Fetal echocardiograms were performed with the use of FI and HI in 58 fetuses, image quality and visualization of left and right atria, left and right ventricles, mitral and tricuspid valves, aortic and pulmonary valves, left and right ventricular outflow tracts were evaluated and compared between FI and HI. Results: Mean HI scores were higher than mean FI scores (2.73±0.43 vs 2.16±0.69, P<0.001)for all the cardiovascular structures evaluated. Compared with FI, HI improved the image quality and visualization of fetal cardiac structures in subjects with both good (2.73±0.43 vs 2.88±0.32, P<0.001) and suboptimal (1.65±0.41 vs 2.58±0.47, P<0.001) echocardiographic windows. The interobserver correlation coefficient for the grading scores was 0.74 (P<0.001). Conclusions: harmonic imaging enhances and improves the image quality of fetal echocardiography; and has important potential role in cardiac imaging in the fetus. 相似文献