灵魂的绞杀与欲望的宣泄--中日当代小说的人性与精神分析     

毛克强 《宜宾学院学报》2004,4(4):58-62

处于同一文化圈的中、日当代小说,在双重人格的刻画和复杂人性的描写方面,有许多相同和可比之处.日本一些当代小说受到复杂的文化影响,中国儒家文化和佛教文化使他们的文化性格处于隐思和内向,而西方基督教文化和精神分析学又使他们具有原罪意识和原欲的冲动,神道教和武士道精神并未完全消亡.在现代社会中,文化的冲突更加激烈,致使人的灵魂的绞杀更加深重,于是人物命运的指向较多的是走向死亡.中国小说在描写人的复杂人性时,更多是在于表层欲望的宣泄,较少触及人的精神层面,应当说中国作家对复杂人性的描写要肤浅一些.  相似文献   

pH值敏感水凝胶的合成及药物缓释性能研究   总被引：4，自引：0，他引：4  

钟世华 《湖南城市学院学报》2003,24(3):100-102

聚乙二醇(PEG)与丙烯酰氯反应合成聚乙二醇双丙烯酸酯(PEGDA)，然后以PEGDA、N—乙烯基—2—此咯烷酮(NVP)及丙烯酸为主要原料，N，N^ —亚甲基双丙烯酰胺(BIS)为交联剂，偶氮二异丁腈(AIBN)为引发剂，采用自由基聚合法合成了对pH值变化敏感的N—乙烯基—2—吡咯烷酮—丙烯酸—聚乙二醇双丙烯酸酯交联共聚物(po1y[NVP-AA-PEGDA])水凝胶．利用该共聚物为载体对抗癌药5—氟脲密啶(5—FU)进行包埋，并在SIF及SGF缓冲溶液中于37℃进行体外释药研究．结果表明，在pH值较小的缓释介质中药物释放曲线较平缓，释药周期较长，同时最终的平衡释药百分数也较小；随着样品中PEGDA量的减少，释药曲线趋于平缓，释药周期变长，最终的平衡释药百分数成小．  相似文献   

论校园体育文化建设的六大支柱     

任莲香  袁音  王安平  钟全宏 《甘肃高师学报》2008,13(4):106-109

领导意识、组织机构、教育引导、竞赛体系、运动氛围和优秀运动队组建等是校园体育文化建设的六大支柱。通过对这六方面的基本要求的分析,使校园体育文化建设支撑体系的基本内容、方式方法和目标任务更加明确具体、利于建设。  相似文献   

出口垄断协议豁免制度研究     

周霞 《哈尔滨学院学报》2008,29(11):38-40

我国出口垄断协议豁免制度虽然确立,但这种简单与原则性的规定缺乏可操作性。因此文章认为,应设置反垄断豁免的审批等程序规范,实行反垄断豁免的公示和监督制度,规定影响我国市场的外国出口垄断协议行为的调查和控制制度,明确出口垄断协议豁免行为的职能机构。  相似文献   

Gene expression and apoptosis response in hepatocellular carcinoma cells induced by biocompatible polymer/magnetic nanoparticles containing 5-fluorouracil     

《Electronic Journal of Biotechnology》2021

BackgroundSuper-paramagnetic iron oxide nanoparticles (SPION) contain a chemotherapeutic drug and are regarded as a promising technique for improving targeted delivery into cancer cells.ResultsIn this study, the fabrication of 5-fluorouracil (5-FU) was investigated with loaded Dextran (DEX-SPION) using the co-precipitation technique and conjugated by folate (FA). These nanoparticles (NPs) were employed as carriers and anticancer compounds against liver cancer cells in vitro. Structural, magnetic, morphological characterization, size, and drug loading activities of the obtained FA-DEX-5-FU-SPION NPs were checked using FTIR, VSM, FESEM, TEM, DLS, and zeta potential techniques. The cellular toxicity effect of FA-DEX-5-FU-SPION NPs was evaluated using the MTT test on liver cancer (SNU-423) and healthy cells (LO2). Furthermore, the apoptosis measurement and the expression levels of NF-1, Her-2/neu, c-Raf-1, and Wnt-1 genes were evaluated post-treatment using flow cytometry and RT-PCR, respectively. The obtained NPs were spherical with a suitable dispersity without noticeable aggregation. The size of the NPs, polydispersity, and zeta were 74 ± 13 nm, 0.080 and −45 mV, respectively. The results of the encapsulation efficiency of the nano-compound showed highly colloidal stability and proper drug maintenance. The results indicated that FA-DEX-5-FU-SPION demonstrated a sustained release profile of 5-FU in both phosphate and citrate buffer solutions separately, with higher cytotoxicity against SNU-423 cells than against other cells types. These findings suggest that FA-DEX-SPION NPs exert synergistic effects for targeting intracellular delivery of 5-FU, apoptosis induction, and gene expression stimulation.ConclusionsThe findings proved that FA-DEX-5-FU-SPION presented remarkable antitumor properties; no adverse subsequences were revealed against normal cells.How to cite: Mahdia SA, Kadhimb AA, Albukhaty S, et al. Gene expression and apoptosis response in hepatocellular carcinoma cells induced by biocompatible polymer/magnetic nanoparticles containing 5-fluorouracil. Electron J Biotechnol 2021;52. https://doi.org/10.1016/j.ejbt.2021.04.001  相似文献   

Improved myocardial perfusion and cardiac function by controlled-release basic fibroblast growth factor using fibrin glue in a canine infarct model     

Nie SP  Wang X  Qiao SB  Zeng QT  Jiang JQ  Liu XQ  Zhu XM  Cao GX  Ma CS 《Journal of Zhejiang University. Science. B》2010,11(12):895-904

Objective: Angiogenic therapy is emerging as a potential strategy for the treatment of ischemic heart disease but is limited by a relatively short half-life of growth factors.Fibrin glue (FG) provides a reservoir for controlledrelease of growth factors.The aim of this study was to evaluate the effects of basic fibroblast growth factor (bFGF) incorporating FG on angiogenesis and cardiac performance in a canine infarct model.Methods: Acute myocardial infarction was induced by ligation of the left anterior descending coronary artery (LAD).Group I (n=6) underwent ligation of LAD alone.In Group II,transmural channels were created in the infarct area (n=6).In Group III,nontransmural channels were created to locate FG cylinders containing bFGF (n=6).Eight weeks after operation,myocardial perfusion was assessed by single photon emission computed tomography,cardiac function by echocardiography,and vascular development by immunohistochemical staining.Results: Total vascular density and the number of large vessels (internal diameter ≥50 μm) were dramatically higher in Group III than in Groups I and II at eight weeks.Only the controlled-release group exhibited an improvement in regional myocardial perfusion associated with lower defect score.Animals in Group III presented improved cardiac regional systolic and diastolic functions as well as global systolic function in comparison with the other two groups.Conclusions: Enhanced and sustained angiogenic response can be achieved by controlled-release bFGF incorporating FG within transmyocardial laser channels,thus enabling improvement in myocardial perfusion and cardiac function.  相似文献   

智能型断路器的研制     

许胜辉 《武汉职业技术学院学报》2010,9(5):76-79

脱扣器是断路器的核心元件,脱扣器的智能化可以大大地推动断路器智能化的发展进程。首先介绍了智能断路器的特点、现状和发展趋势等,然后根据其性能、原理、特点入手,分步对其结构零部件进行设计。智能脱扣器是设计的重点,利用微电子技术及数字信号处理技术,采用数字信号处理器（DPS芯片）作为主控单元,来对其它外围电路进行控制。最后,对软件程序的进行设计,设计的重点是：快速傅立叶变换在定点DSP上的实现,并给出相应的实验结果。  相似文献   

建构我国环境权法律制度刍议     

张龙 《滨州学院学报》2010,26(1):77-80

对于人与环境关系的诸多认识中保护环境的观念可谓由来已久,但是提出并形成独立的环境权概念和体系却是晚近的事情,距今也不过半个世纪。所谓环境权是指公民、法人等组织团体和人类(包括后代人)所拥有的享有适宜健康和良好生活环境,合理利用环境资源以及有效参与国家环境管理和决策的权利。它包含程序性权利和实体性权利,是一种新型人权。  相似文献   

工作记忆、注意与一般液态智力     

王金娥 《和田师范专科学校学报》2010,29(1):56-57

许多研究表明工作记忆与智力,注意与智力,工作记忆与注意之间都存在着密切的联系。然而,不同的研究得出不同的结论：工作记忆与选择注意之间具有显著相关,而与维持注意相关不显著：一般液态智力与维持注意相关显著,而与选择注意相关不显著。本研究对这方面的实证研究进行总结分析,得出工作记忆、注意与一般液态智力之间的关系与其所选用的测试材料及其所应用的注意评定测验有关。  相似文献   

教育功能释放的三重境界     

肖露 《沈阳教育学院学报》2010,12(6):23-25,29

论述了教育的功能,认为本体功能是培养人,教育的其他功能都只是其派生功能。依据教育的主体——人的“存在状态”,将教育功能的释放分成生存境界、生活境界和生命境界。分析了在对人的培养和对社会发展两方面分别体现为个体谋生功能、“成事”功能;个体乐生功能、“成人”功能;个体享用功能、“成己”功能。这三层境界是相互交织、相互转化的螺旋上升过程;是追求教育功能从有用到有意义,从有限到无限的过程。  相似文献