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11.
R. Katyal S V Rana S. Ojha V. Singh R. P. Aggarwal 《Indian journal of clinical biochemistry : IJCB》2005,20(1):118-122
The aim of the study was to evaluate the influence of rotavirus (RV) and soyabean trypsin inhibitor (TI) on lipid composition
and uptake of glucose and glycine in rotavirus (RV) infected malnourished (PEM) infant mice. Malnutrition was achieved in
animals by doubling the litter size. Cholesterol (Ch) and phospholipd (PL) contents, uptake levels of glucose and glycine
were determined in jejunum and ileum portion of small intestine. Increase in Ch/PL ratios was observed in PEM+RV group. The
levels became comparable in PEM+RV+TI as compared to PEM. Uptake levels of glucose and glycine increased in PEM animals. With
rotavirus (PEM+RV+TI group), the levels decreased which became comparable to PEM. Changes in uptake and lipid composition
with rotavirus and trypsin inhibitor may be responsible for altering membrane fluidity and organization during rotavirus diarrhea.
The results establish the importance of trypsin inhibitor during oral infection with rotavirus. 相似文献
12.
试验研究了益母草提取物对小鼠脾脏发育的影响。试验选用60只健康小鼠,随机分为试验组和对照组,益母草提取物按0%和0.05%添加到对照组和试验组小鼠的基础日粮中,试验期为54d。试验结束时,从各组随机抽取15只小鼠进行屠宰,采集小鼠的脾脏样本。应用组织学方法制作组织切片,显微观察益母草提取物对小鼠脾脏发育的影响。结果显示:实验组小鼠白髓数量增多,脾小体面积增大,脾索淋巴细胞增多,边缘区淋巴细胞也增多。益母草提取物作为饲料添加剂对小鼠脾脏的发育有明显的促进作用。 相似文献
13.
本文观察了拟黑多刺蚁匀浆液对小鼠血中SOD活性、MAO含量及脾脏脂褐素的影响。给药组老龄小鼠与老年对照组比较RBC-SOD增高(P<0.01),脾脏脂褐素分布相对减少,而血浆MAO水平显著降低(P<0.01);与成年对照比较二酶均未见显著差异。 相似文献
14.
目的：研究双氢青蒿素哌喹对约氏疟原虫感染小鼠红细胞感染率变化的影响。方法：用约氏疟原虫感染小鼠。于感染后第3天开始。连续3d口服双氢青蒿素哌喹20mg／kg。于感染后第2天开始每天观察其红细胞感染情况并计算感染率。结果：约氏疟原虫感染后。小鼠红细胞感染率逐渐上升。应用双氢青蒿素哌喹治疗后。红细胞感染率明显降低，与未治疗组相比差异显著（P〈0．05）。结论：从原虫血症的变化上证明双氢青蒿素哌喹具有确切的抗疟效果。 相似文献
15.
地塞米松对小鼠腭突细胞增殖和分布的影响 总被引：3，自引：2，他引：1
目的:通过比较不同时期正常胎鼠和地塞米松诱导的腭裂胎鼠中间嵴上皮细胞(MEE)和腭突间充质细胞(EPM)的数目和分布情况,初步探讨腭裂形成的机制。方法:选取孕鼠30只,随机分为对照组和实验组,实验组于妊娠GD11.5腹腔内注射50mg/kg地塞米松,干扰胎鼠腭突发育,分别于GD12.5,13.5,14.5,15.5,16.5时取材,共获胚胎284只,取头部标本做冠状切片,切片厚6μm,HE染色,光镜下观察,记录MEE细胞的数量和EPM细胞的数目和分布情况。结果:实验组和对照组腭突突部EPM明显多于根部,且实验组EPM发育滞后于对照组;GD13.5,14.5,15.5时实验组EPM细胞数量少于对照组;实验组MEE细胞在GD15.5,16.5时大量存在,而对照组GD14.5时开始融合甚至消失。结论:地塞米松导致的EPM细胞增殖抑制和MEE细胞的转归异常,是腭裂形成的重要原因。 相似文献
16.
小鼠经腹腔注射０．３３ｍｇ／ｋｇ、１．０ｍｇ／ｋｇ、３．０ｍｇ／ｋｇ的偏钒酸钠（ＮａＶｏ３），染毒第二、四、六周末每组随机取５只小鼠经股动脉取血，按常规计算血细胞及血红蛋白（Ｈｂ）含量的变化。结果表明：染毒第六周末，ＮａＶｏ２对红细胞（ＲＢＣ）影响最明显，各剂量组与对照组比较均有高度显著性差异（ｐ＜Ｏ．０１）。而白细胞（ＷＢＣ）明显减少仅见于３．０ｍｇ／Ｋｇ组（Ｐ＜０．０１）。血小板（ｐｔ）１．０ｍｇ／ｋｇ、３．０ｍｇ／ｋｇ组均明显减少（Ｐ＜０．０１）。Ｈｂ含量，染毒第二周末，各剂量组均降低（Ｐ＜０．０５）。第四、六周末１．０ｍｇ／ｋｇ、３．０ｍｇ／ｋｇ有显著降低（Ｐ＜０．０１）。呈现良好的剂量效应关系。 相似文献
17.
旋毛虫感染小鼠肌组织的病理研究 总被引：1，自引：0，他引：1
目的：探讨旋毛虫感染小鼠肌组织的病理变化。方法：取40只昆明小鼠。用灌胃法建立轻度（L组）、重度（H组）旋毛虫感染动物模型，观察其膈肌组织的病理变化。结果：第1周时可见肌纤维变性、水肿、肌膜破坏等病理变化；肌幼虫囊包周围有较多的炎症细胞浸润。第5周时发生玻璃样变性，出现透明带。第7周时，幼虫及囊包周围开始有钙盐沉积。L组、H组两组除感染第13周外．其余时间病理变化没有观察到明显的差异。结论：感染旋毛虫后，肌组织出现变性、水肿、炎细胞浸润及幼虫囊包的钙化等病理变化，为旋毛虫病的病理检测提供有用的基础资料． 相似文献
18.
目的:观察竹节参的有效成分竹节参总皂苷(total saponins of Panax japonicus,TSPJ)的抗氧化作用;方法:通过小鼠血清GSH-PX、SOD、MDA检测观察TSPJ的抗氧化作用.结果:TSPJ(75,150,300mg.kg-1)ig能显著升高血清GSH-PX,SOD活性,降低血清MDA含量.结论:TSPJ具有明显的抗氧化作用,与空白对照组比较差异性显著。 相似文献
19.
Manish K. Singh Shailendra Dwivedi Suraj S. Yadav Praveen Sharma Sanjay Khattri 《Indian journal of clinical biochemistry : IJCB》2014,29(1):29-37
Arsenic a metalloid and environmental contaminated has been found to be associated with public health problems in the affected areas. It is naturally occurred in groundwater and its accumulation in plant and animals leads to toxicity in several tissues most notably hepatic organ. Arsenic exposures (3 mg/kg body weight/day for 30 days) in mice exhibited increased arsenic and Zn levels in hepatocytes associated with enhanced oxidative stress in hepatocytes while there were no significantly changes were observed in Cu level. An increase in the lipid peroxidation and decrease in the levels of reduced glutathione and activity of superoxide dismutase, catalase, and glutathione peroxidase were observed in arsenic treated mice as compared to controls. Arsenic exposure in mice also caused a significant change in serum biomarkers in the SGOT, SGPT and creatinine as compared to the controls. There were no significant changes in the serum levels of total protein in these mice. Co-administration of arsenic and fruit extract of amla (500 mg/kg body weight/day for 30 days) caused a significant reduction of arsenic transference associated with significantly decreases hepatic arsenic levels and balanced the antioxidant enzyme and levels of serum hepatic enzymes like SGOT and SGPT. The results of the present study clearly demonstrate the antioxidant property of amla that could be responsible for its protective efficacy in arsenic induced hepatic toxicity. 相似文献
20.
姜黄素对小鼠抗氧化酶活性及NO含量的影响 总被引：4，自引：0，他引：4
选取60只小鼠,随机分成四组(A、B、C、D),A组为对照组,饲喂基础饲料;B、C、D组分别在基础饲料中添加0.02%、0.04%、0.06%的姜黄素.正常饲养15d后,屠宰测定小鼠血清、肝脏、心脏、脑组织中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)的活性及丙二醛(MDA)、NO的含量.结果表明,小鼠采食添加姜黄素的饲料后,体内抗氧化酶SOD、CAT活性升高,MDA、NO含量下降. 相似文献