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1.
龙胆泻肝汤临床应用较广，功效清泻肝胆实火，清利肝经湿热。主治；肝胆实火上炎证，头痛目赤，胁痛，口苦，耳聋、耳肿。肝经湿热证，阴肿，阴瘁，筋痿，阴汗，小便淋浊或妇女带下黄臭等症。笔者用本方治疗高血压，心悸等取得良好疗效。 相似文献
2.
目的:研究软肝散对慢性乙型肝炎肝纤维化的治疗效果.方法:选取180例慢性乙型肝炎患者为研究对象,随机分两组,治疗组给予益肝灵和软肝散口服,对照组给予益肝灵口服,治疗6个月后评定疗效.主要观察项目为治疗前后患者的临床症状、体征、肝功能(AST、ALT、A/G)和血清肝纤维化指标(HA、LN、PCⅢ、Ⅳ-C)的变化情况.结果:两组病例治疗后临床主要症状、体征、肝功能和肝纤维化指标较治疗治疗前均有较大改善,治疗组总有效率为91.11％,对照组总有效率为80％,治疗组效果明显好于对照组.结论:软肝散在治疗慢性乙型病毒性肝炎肝纤维化方面具有明显缓解临床症状和体征,改善肝功能及肝纤维化指标的作用,值得在临床上推广使用. 相似文献
3.
目的:为了研究探讨中药治疗精液不化诱发的不育症的疗效。方法:根据婚后夫妻生活在一起,而两年来未受孕者,其精液化验检查30分钟以上不液化,采用中医清利肝胆湿热的方法,方用龙胆泻肝汤为基本方作为治疗组,西药为对照组。共完成212例,其治疗组128例,对照组84例,对临床症状及精液检查,诊断,疗效标准均参照国内外统一规定,分别进行统计学处理及进行综合分析总结。结果:对照组和治疗组经X2检验均P<0.01。结论:两组治疗有显著性的差异,中药组治疗优于西药组治疗。 相似文献
4.
《科学中国人》2015,(12)
目的:分析和研究叶下珠片结合拉米夫定治疗慢性乙型肝炎的临床疗效。方法:选取2012年10月—2013年10月慢性乙型肝炎患者126例,将其按双盲随机法分为观察组63例与对照组63例。对照组患者给予拉米夫定片治疗;观察组患者在对照组治疗基础上加用叶下珠片治疗,将两组患者治疗12个月后的效果及不良反应发生率进行对比。结果:两组患者乙肝病毒基因、乙型肝炎E抗原、乙肝表现抗原等转阴率相比较:观察组各项指标均高于对照组(P0.05)。两组患者谷丙转氨酶复常率相比较:两组无明显差异(P0.05)。两组患者治疗期间不良反应发生率相比较:两组无明显差异(P0.05)。结论:将叶下珠片与拉米夫定联合应用于慢性乙型肝炎患者治疗中,其能够有效抑制乙肝病毒基因复制,促进患者肝功能恢复,延缓肝纤维化进程,对提高治疗效果及患者生活质量均有重要作用。 相似文献
5.
《西藏科技》2016,(9)
目的文章主要是为了研究复方甘草酸苷注射液治疗高海拔地区乙型病毒性肝炎高胆红素血症的治疗效果。研究方法是把64例总胆红素171umol/L的乙型病毒性肝炎患者随机分为2组,治疗组(32)例,用复方甘草酸苷注射液120ml静滴,每天1次;对照组(32例)用肝泰乐0.665g静滴每天1次。两组同时应用维生素类、能量合剂及祛黄药,整个疗程维持4个星期。比较两组患者治疗前后的临床症状、生命体征和肝功能变化等情况。研究结果表明治疗组患者的临床症状、体征改善明显,治疗前后胆红素(TBiL)、丙氨酸氨基转移酶(ALT)、天门冬氨基转移酶(AST)和谷氨酰转肽酶(GGT)下降程度均比对照组明显(P0.05),治疗组总有效率达100%,显著高于对照组患者的71.9%(P0.01),其差异有统计学显著意义,整个治疗期间没有发现有复方甘草酸苷注射液相关的任何不良反应发生。结论复方甘草酸苷注射液治疗高海拔地区乙型肝炎高胆红素血症有明显疗效而且安全可靠。 相似文献
6.
目的:观察柴芍六君子汤联合拉米夫定治疗慢性乙型性肝炎的临床疗效。方法:将60例符合纳入标准的患者按照随机数字表法分为试验组30例和对照组30例,对照组予拉米夫定抗病毒治疗,试验组在对照组基础上给加用柴芍六君子汤治疗,治疗48周为1个疗程。观察两组患者在治疗后4周、12周、24周、48周时ALT、AST情况;HBe Ag血清学转换率;HBV-DNA阴转率;临床症状改善等评价柴芍六君子汤治疗慢性乙型肝炎的疗效。结果:试验组在肝功能恢复;HBe Ag血清学转换率;HBV-DNA阴转率;临床症状改善等方面均优于对照组(P0.05)。结论:柴芍六君子汤可提高拉米夫定治疗慢性乙型肝炎的疗效,值得临床推广应用。 相似文献
7.
《大众科技》2015,(8)
目的:通过瞬时弹性成像扫描仪(Fibro Scan)以及彩色多普勒超声显像仪观察解毒化瘀颗粒治疗慢性乙型肝炎肝纤维化的临床疗效。方法:将200例乙型肝炎肝纤维化患者,随机分为解毒化瘀颗粒组和大黄蛰虫丸组,比较两组入组前基线特征,疗程30天,观察治疗前后患者肝脏彩超脾脏厚度、肝门静脉宽度、门静脉血流情况变化以及Fibro Scan扫描的肝硬度值(Stiffne值)的影响。结果:经过治疗后,治疗组患者脾脏厚度、肝门静脉宽度,门静脉流速(PVV)、肝动脉搏动指数(HA-PI)和肝血管指数(LVI)明显较治疗前降低,治疗组Fibro Scan扫描结果治疗前后比较,FS值显著下降(P0.01),而对照组无明显变化(P0.05)。结论:解毒化瘀颗粒对改善慢性乙型肝炎肝纤维化脾脏厚度、肝门静脉宽度、肝血流动力学、肝硬度值以及阻止其进程有良好疗效。 相似文献
8.
参芪扶正注射液对症治疗肝炎后肝硬化的临床观察 总被引：2，自引：0，他引：2
尝试采用参芪扶正注射液进行中医对症治疗，针对肝脾不足、气阴两虚型的肝炎后肝硬化患者，治疗组和对照组各30例，应用参芪扶正注射液250ml静脉输注，1次／日。对照组与治疗组均采用综合保肝治疗，两组均以三周为一疗程，可进行1～2个疗程。结果显示治疗组在乏力、胸闷、气短、心悸、自汗方面的缓解率均明显高于对照组。治疗组在ALT、AST、ALB、肾功能(血肌酐)和凝血机制方面(凝血酶原活动度PA)的改善均明显好于对照组，而对于血清胆红素TBil的改善情况两组患者治疗前后对比无显著性差异。表明参芪扶正注射液不但对肝脾不足、气阴两虚型的慢性肝炎及肝炎后肝硬化患者的中医临床症状的改善、肝功能的恢复和缩短病程起到积极的作用，而且无毒副作用。 相似文献
9.
目的:探究天然牛磺酸联合肝宁方治疗肝炎后肝硬化腹水的临床疗效。方法选取200例肝炎后肝硬化腹水患者,随机分为观察组和对照组,各100例。观察组采用天然牛磺酸联合肝宁方的方法治疗,对照组则采用单纯西医治疗。观察比较2组患者的临床治疗效果。结果:经治疗后:(1)观察组患者治疗效果的总有效率高达94.0%,显著高于对照组的79.0%(P0.05);(2)治疗后观察组ALB(44.72±2.09)g/L、ALT(57.25±21.09)U/L、TBLL(41.72±7.09)μmol/L,均优于对照组(40.18±1.06)g/L、(82.58±42.35)U/L、(47.18±15.06)μmol/L(P0.05)。结论:天然牛磺酸联合肝宁方治疗肝炎后肝硬化腹水临床疗效显著,临床上值得广泛推广使用。 相似文献
10.
目的:探讨中药复方海珠益肝化纤方对肝纤维化大鼠α-SMA和TGFβ1表达的影响。方法:将60只Wistar健康大鼠随机分为正常对照组、模型对照组、中药治疗组和阳性对照组,各15只。除正常对照组外,余下三组均采用四氯化碳(CCL4)造模8周制备肝纤维化模型。造模成功后,正常对照组和模型对照组给予0.9%生理盐水溶液,阳性对照组予秋水仙碱混悬液(0.25mg/kg/d),中药治疗组予海珠益肝化纤方混悬液(5m L/100g/d),连续用药治疗6周。观察各组大鼠肝功能(AST、ALT)、肝纤维化指标(HA、PCⅢ、IV-C、LN)、α-SMA和TGFβ1的变化。结果:与模型对照组相相比,阳性对照组、中药治疗组大鼠ALT、AST、HA、PCⅢ、IV-C、LN、α-SMA和TGFβ1水平下降(P0.05);与阳性对照组相比较,中药对照组大鼠ALT、AST、HA、PCⅢ、IV-C、LN、α-SMA和TGFβ1水平显著性降低,差异具有统计学意义(P0.05);海珠益肝化纤方组大鼠肝纤维化程度低于秋水仙碱组大鼠。结论:海珠益肝化纤方可降低CCL4诱导的肝纤维化大鼠α-SMA和TGFβ1的表达,抑制肝纤维化的进展。 相似文献
11.
Prasad P. Torkadi I. C. Apte A. K. Bhute 《Indian journal of clinical biochemistry : IJCB》2014,29(1):79-83
Alcoholic liver disease (ALD) is due to excessive alcohol intake for long duration. Distinguishing ALD from non-ALD (non-alcoholic steatohepatitis, hepatitis of viral origin) is difficult as patient may deny alcohol abuse. Clinical examination, histology and serology may not differentiate these conditions. Accurate diagnosis is important as management of ALD differs from non-ALD patients. The aim of our study was (1) To evaluate the patients of ALD and non-ALD by biochemical parameters compared to controls, (2) To assess whether these parameters can differentiate ALD from non-ALD. Study was carried out on 50 patients of ALD in group I and 35 patients of NASH (non-alcoholic steatohepatitis) and acute viral hepatitis each in group II. Age matched healthy controls n = 50. Selection criteria—history of alcohol intake (amount and duration), clinical examination, sonography of abdomen, serum alanine transaminase (ALT) and bilirubin levels. Blood samples were analyzed for bilirubin, aspartate transaminase (AST), ALT, alkaline phosphatase (ALP), gamma glutamyl transferase (GGT) by kinetic method. Statistical analysis was done by Student unpaired ‘t’ test. Patients of ALD have raised AST/ALT ratio (De Ritis ratio) (>2), ALP and GGT compared to controls (P < 0.01).There is significant difference in AST/ALT ratio, serum GGT and ALP in ALD group compared to that in NASH and acute viral hepatitis (P < 0.05). This study suggests that De Ritis ratio >2 in ALD patients may be due to alcohol induced hepatic mitochondrial injury and pyridoxine deficiency. High GGT and ALP values may indicate enzyme induction by alcohol and mild cholestasis. Thus ALD patients have severe hepatic damage. De Ritis ratio <1 and normal to mild elevation in GGT level in NASH and acute viral hepatitis suggest mild hepatic injury of non-alcoholic origin. Our study concludes that ALD patients can be differentiated from NASH and acute viral hepatitis with certainty by measuring serum AST/ALT ratio, GGT and ALP. These biochemical parameters may help clinicians to support the diagnosis of ALD and non-ALD. 相似文献
12.
Pradeep Naik Venkataraman Sritharan Premsagar Bandi Mallikarjuna Madhavarapu 《Indian journal of clinical biochemistry : IJCB》2013,28(1):38-45
Liver transplantation means surgical replacement of a diseased liver with a healthy liver. The survival rate used to be 30 % after 1 year and LTx was considered to be the last procedure when all medical or surgical intervention failed. Advances in donor organ preservation, surgical techniques, patient selection, immunosuppressive regimens and treatments for opportunistic infections all have contributed to substantially improve the survival rates. Despite substantial technological, medical and surgical advances, liver transplantation remains a complex procedure that is accompanied by significant morbidity and mortality. The post-operative outcome of each patient varies greatly depending on the patient’s pre- operative state, quality of the donated organ and the complexity of the surgery. Complications occur both immediately post transplant and in the long term. Most of the problems can be satisfactorily assessed with a panel of routine LFTs results of which are generated quickly, cheaply on the analyzer which operates 24 h. Liver Function Test identifies the presence of problem but not problem itself. Abnormal results can be meaningful only when used with clinical data, radiological findings. The study includes 75 post LTx patients in three groups adults (non ACR), Pediatrics and ACR. All recipients were on immunosuppressive therapy (tacrolimus, mycophenolate and methylprednisolone), antiviral (ganciclovir), antiprotozoal, antibacterial and antifungal (fluconazole). 5 mL of blood was drawn in plain vacutainer from the post LTx patients every day for 15 days and LFT and GGT was done. Routinely performed liver function tests correlates well with clinical complications involving liver in the transplant patients. Instead of daily testing, may be alternate day analysis of LFT should be sufficient for effective monitoring of patients. The total protein and albumin and the transaminases offer little help in monitoring LFT post LTx. The elevated levels of serum GGT and ALP may be related to chronic immune damage to the transplanted liver. Serum GGT and ALP can be used as early markers for diagnosing biliary complications and can be used to asses adequacy of endoscopic treatment in the group of patients presenting early. Thus, most of the problems can be satisfactorily assed with a panel of routine LFTs generated quickly, cheaply on analyzer which operates 24 h each day. However, it must be emphasized that LFTs may identify the presence of problems but not the problem itself and the abnormal results are meaningful only when correlated with other clinical information. 相似文献
13.
Mohamed Hessien Mohamed Ayad Wafaa M. Ibrahim Batoul Izz ulArab 《Indian journal of clinical biochemistry : IJCB》2015,30(2):210-216
This work was designated to monitor the coagulation abnormalities associated with the gradual progression of liver diseases. The study included fifty patients; forty were diagnosed with liver cirrhosis with different stages categorized according to the Childs-Pugh classification and another ten patients were diagnosed with hepatocellular carcinoma (HCC). Haemostatic variables including fibrinogen (FI), calcium (FIV), transglutaminase (FXIII), prothrombin time (PT) and platelet count were estimated in patients and compared with the baseline levels of healthy subjects (n = 10). The results demonstrated that the fibrinogen level was progressively decreased, whereas PT was progressively prolonged in Child A, Child B and Child C groups. The maximum deterioration was observed in HCC patients. Calcium significantly increased in mild (Child A) and moderate (Child B) but not in Child C cirrhosis and HCC patients. FXIII level did not show any significant changes in cirrhotic patients compared to healthy group. Some of the haemostatic variables we investigated were correlated with serum albumin and bilirubin but not with aminotransferases (ALT and AST). The results indicated that the haemostatic abnormalities in fibrinogen, calcium and PT (but not FXIII) were deteriorated in parallel with the gradual regression of the constitutional function of liver. 相似文献
14.
肝纤维化是各种原因肝损伤后引起的肝脏复杂病理变化,国内外近年来研究表明,如果积极干预,尤其是在早期介入阻断肝纤维化的进展,甚至可以在一定程度上逆转肝纤维化,因此明确肝纤维化的诱发因素、发展机制及其可逆指标的检测对治疗慢性肝病肝纤维化即预防肝纤维化进展为肝硬化有一定的意义.但是目前肝纤维化的发生进展的机制仍未有较为明确的定论.文章通过研究近年来阐述肝纤维化发生、发展机制相关的文献,并对文献中有证据支持的肝纤维化发展过程中的相关机制做总结归纳,为肝纤维化的治疗及验证肝纤维化相关实验设计提供思路及理论支持. 相似文献
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Kaushik Kar Anindya Dasgupta M. Vijaya Bhaskar K. Sudhakar 《Indian journal of clinical biochemistry : IJCB》2014,29(2):232-237
Decompensation followed by death is the most serious outcome in patients suffering from cirrhosis of the liver. Alteration of trace elements may play a vital role in the process of decompensation. To examine the change in status of trace elements during the decompensation process, we analysed the zinc, copper, iron, magnesium, bilirubin and albumin levels in the serum of compensated (n = 34) and decompensated (n = 31) liver cirrhosis patients and compared them with healthy control group (n = 36) by post hoc ANOVA. We observed significant alteration in the selected micronutrients in the diseased group relative to healthy controls (P < 0.05). Moreover, mean serum zinc and iron levels were significantly lower with a higher level of serum copper in decompensated cirrhosis group than in compensated group (P < 0.05). However, no significant decrease of serum magnesium was found between the two diseased groups. Our findings imply that the trace elements like zinc, copper and iron might exert important contributory roles in decompensation process in liver cirrhosis and hence, may be utilized as important biomarkers for these patients. Furthermore, we propose that replacements of those micronutrients at an early stage can delay or prevent the severe outcomes like hepatic encephalopathy, gastrointestinal bleeding, severe jaundice or ascites in these patients. 相似文献
18.
本实验中采用了新药物研究中认可的ＣＣＬ４诱导大白鼠慢性肝损害的模型作为研究对象．病理结果说明使用软肝丸有良好的抗细胞坏死，能明显抑制肝纤维化过程，促进肝细胞再生作用．药效学的研究，也提示软肝丸可以降低血清ＡＬＴ及肝组织中的羟脯氨酸的含量． 相似文献
19.
A number of factors are linked with non-alcoholic fatty liver diseases (NAFLD), a condition that ranges from clinically benign
fatty liver to its more severe form, non alcoholic steatohepatitis (NASH). In this study, we evaluated the role of cytokines
secreted from adipose tissue in the pathogenesis and progression of NAFLD. We also compared anthropometric profile, lipid
profile and insulin resistance data in 105 NAFLD patients with 77 normal subjects. These subjects showed a normal serum albumin
level, prothrombin time and renal function but elevated aminotransferases. Predisposing factors were diabetes mellitus (35%),
overweight (56%) and hyperlipidemia (44%). Insulin resistance (IR), determined by homeostasis model assessment (HOMA) was
confirmed in 70% patients with NAFLD and 42% patients fulfilled the minimum criteria for insulin resistance syndrome (IRS).
NAFLD patients showed elevated levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-α, and interleukin (IL)-6,
while anti-inflammatory cytokines IL-4 level decreased and IL-10 level remain unchanged; however, TGF-β1 level elevated significantly
compared to normal subjects. While insulin level and HOMA-IR both were significantly positively correlated with BMI, waist-to-hip
ratio, total cholesterol, VLDL-cholesterol, triglyceride and TGF-β1; glucose, IL-6 and TNF-α levels were significantly positively
correlated with HOMA-IR only. In conclusion, pro-inflammatory cytokines play an important link between metabolic and liver
disorders in the fat accumulation, and thereby cause IR, inflammation and liver fibrosis. 相似文献
20.
Paraoxonase is an anti-oxidant enzyme, which circulates in the plasma, tightly bound to HDL. This enzyme is known to be synthesized
in the liver. This study was carried out in order to ascertain the diagnostic utility of this enzyme in acute liver disease.
Serum basal as well as salt (NaCl) stimulated paraoxonase was estimated in 50 patients with an established diagnosis of acute
liver disease and also in 50 healthy blood donors. Paraoxonase levels were significantly lower in patients as compared with
controls (P < 0.05). The ‘receiver operating characteristic’ plot showed that this enzyme has a high degree of sensitivity and specificity
for the diagnosis acute liver disease. Serum PON is likely to emerge as an additional test of liver function, as it encompasses
three different attributes of hepatic function namely, synthetic capacity, detoxication and secretory functions. 相似文献