药物小分子与生物大分子相互作用的研究进展     

李悦 《天津职业院校联合学报》2013,(10):110-115

药物小分子与生物大分子相互作用的研究是涉及到化学与生命科学等多个领域的交叉课题。血清蛋白（SA）与脱氧核糖核酸（DNA）是生物体内的重要转运载体和生命物质,对药物在体内的分布、代谢过程起到至关重要的作用。本文以相互作用的分子机制为导向,对药物小分子与生物大分子相互作用的原理和分析方法以及最新进展进行综述,为深入探索生命物质的结构与功能以及开发设计高效低毒的新药提供了理论依据。  相似文献   

Engagement as Co-Generative Theorizing     

Stanley Deetz 《Journal of Applied Communication Research》2013,41(3):289-297

To meet current and ever shifting problems people continually need new and better ways to attend to, talk about, and respond in the world. All communities can have an impoverished language for talking about human interaction and making decisions in times of fundamental and rapid change. Three current impoverishments are discussed. Engaged scholarship using co-generative theorizing can initiate productive conversations enriching the languages of both scholarly and everyday life communities.  相似文献   

Accommodating Translational Research     

Howard Giles 《Journal of Applied Communication Research》2013,41(2):121-127

This is an article in a series illustrating the way scholars in communication have pursued translating their research into practice. The translational nature of communication accommodation theory and examples of its application are the focus of this contribution.  相似文献   

Parental Self-efficacy and Sensitivity During Playtime Interactions with Young Children: Unpacking the Curvilinear Association     

Steven R. Wilson  Patricia E. Gettings  Lisa M. Guntzviller  Elizabeth A. Munz 《Journal of Applied Communication Research》2013,41(4):409-431

Although scholars and service providers typically assume that parental self-efficacy (PSE) facilitates sensitive parenting, this study finds that the association between PSE and observer ratings of parents' sensitivity during free play actually is curvilinear. Parents (33 mothers, 5 fathers) from an intergenerational learning program serving low-income families completed the Self-Efficacy for Parenting Tasks Index and were videotaped during a 15-minute play period with their infant/toddler at program entry. Parents' self-reported PSE is positively, albeit weakly, associated with observer ratings of parental sensitivity from low to moderate levels of self-efficacy but inversely associated with sensitivity from moderate to high self-efficacy. Qualitative analyses show that mothers who report high PSE but are rated as low in sensitivity introduce toys when their child is already engaged, restrict their child's access to toys, physically manipulate their child, and violate their child's proximal space. Parenting education programs need to develop strategies for reaching parents who enter with high levels of confidence but lack knowledge of competent parenting practices.  相似文献   

Adult Child Perceptions of Communication and Humor When the Parent Is Diagnosed with Cancer: A Suggestive Perspective from Communication Theory     

《Qualitative Research Reports in Communication》2013,14(1):67-78

This study examines the function of communication and humor in the older adult parent-adult child dyad when the parent has been diagnosed with cancer. Qualitative data of open-ended data from 46 adult children of a parent recently diagnosed with cancer revealed that discussing diagnosis and treatment procedures was perceived to be a satisfying conversation, whereas withholding information had an adverse affect. The discussion of the parents' feelings during the cancer period was a difficult and complex communicative experience. The Meta-Humorous Interaction Theory (MetaHIT) was used as a conceptual framework to understand the function of appropriate and inappropriate uses of humor in terms of cognitive, affective, and behavioral elements of humor. Humor was often used as a coping or relief function for discussing side effects of cancer treatment. This investigation underscores the importance of understanding how adult children use humorous communication to cope with the unknown conversational territory of a parent's cancer diagnosis.  相似文献   

Unlocking the gates: how and why elite universities are opening up access to their courses,by Taylor Walsh, 2011, Princeton,New Jersey,Princeton University Press, 296 pp., $29.95 (hardback), ISBN 978-0-69-114874-8     

Helen Lentell 《Open Learning》2013,28(2):183-190

This paper presents a case study of the nature of an online community that exists amongst students in a full‐time teacher education program delivered at a distance. Students differentiate between two principal areas of their community—learning and support—and appear to act differently in relation to those areas. The nature of those differences is explored through the students' words as a way of enriching understanding of the complex nature of online learning communities.  相似文献   

An empirical investigation of knowledge management and innovative performance: The case of alliances   总被引：2，自引：0，他引：2  

Xu Jiang  Yuan Li 《Research Policy》2009,38(2):358-368

This paper examines firm-level performance implications of strategic alliances by employing knowledge management practices as intermediaries. Unlike previous research which focuses on partner firm factors, this study investigates how alliance characteristics (i.e., alliance scope and governance) affect interfirm knowledge sharing and creation, and how these two practices and their interaction in turn affect innovative performance. These questions are examined in a sample of 127 German partnering firms. Results show that joint ventures as opposed to contractual alliances are more effective and influential in facilitating knowledge sharing and creation. In contrast, the scope of alliance activities, while positively associated with knowledge sharing, has no direct relationship with knowledge creation. In addition to these results, the study also finds that knowledge sharing, knowledge creation and their interaction significantly contribute to partner firms’ innovative performance.  相似文献   

Evaluating WordBars in exploratory Web search scenarios     

Orland Hoeber  Xue Dong Yang 《Information processing & management》2008

Web searchers commonly have difficulties crafting queries to fulfill their information needs; even after they are able to craft a query, they often find it challenging to evaluate the results of their Web searches. Sources of these problems include the lack of support for constructing and refining queries, and the static nature of the list-based representations of Web search results. WordBars has been developed to assist users in their Web search and exploration tasks. This system provides a visual representation of the frequencies of the terms found in the first 100 document surrogates returned from an initial query, in the form of a histogram. Exploration of the search results is supported through term selection in the histogram, resulting in a re-sorting of the search results based on the use of the selected terms in the document surrogates. Terms from the histogram can be easily added or removed from the query, generating a new set of search results. Examples illustrate how WordBars can provide valuable support for query refinement and search results exploration, both when vague and specific initial queries are provided. User evaluations with both expert and intermediate Web searchers illustrate the benefits of the interactive exploration features of WordBars in terms of effectiveness as well as subjective measures. Although differences were found in the demographics of these two user groups, both were able to benefit from the features of WordBars.  相似文献   

Beyond virtual museums: Experiencing immersive virtual reality in real museums     

Marcello Carrozzino  Massimo Bergamasco   《Journal of Cultural Heritage》2010,11(4):313-458

Contemporary museums are much more than places devoted to the placement and the exhibition of collections and artworks; indeed, they are nowadays considered as a privileged means for communication and play a central role in making culture accessible to the mass audience. One of the keys to approach the general public is the use of new technologies and novel interaction paradigms. These means, which bring with them an undeniable appeal, allow curators to modulate the cultural proposal by structuring different courses for different user profiles. Immersive Virtual reality (VR) is probably one of the most appealing and potentially effective technologies to serve this purpose; nevertheless, it is still quite uncommon to find immersive installations in museums. Starting from our 10 years’ experience in this topic, and following an in-depth survey about these technologies and their use in cultural contexts, we propose a classification of VR installations, specifically oriented to cultural heritage applications, based on their features in terms of interaction and immersion. On the basis of this classification, aiming to provide a tool for framing VR systems which would hopefully suggest indications related to costs, usability and quality of the sensorial experience, we analyze a series of live examples of which we point out strengths and weak points. We then summarize the current state and the very next future, identifying the major issues that prevent these technologies from being actually widespread, and outline proposals for a more pervasive and effective use of Immersive VR for cultural purposes.  相似文献   

Online interaction across three contexts: an analysis of culture and technological affordances     

Todd L. Sandel  Richard Buttny  Mary Varghese 《Journal of Intercultural Communication Research》2019,48(1):52-71

Students were linked virtually across three contexts: U.S., Malaysia, and China. Differences emerged in how student-created messages were constructed and interpreted; these impacted perceived relational affiliation. Messages constructed by students in Malaysia and China exhibited casual talk, greater self-disclosure, requests for personal information, and greater use of emoticons/emoji. Interactions were perceived as informal, friendly, and positive. U.S. students’ messages often showed institutional talk, less self-disclosure, and more attention to the instructor-assigned task. Asian-U.S. student pairs perceived their interactions as formal, less friendly, and less positive. This study shows how online technologies may be afforded and shaped by culture and interaction.  相似文献