罗格列酮和有氧运动对糖尿病糖脂代谢紊乱的干预作用     

胡红梅 《沈阳体育学院学报》2004,23(6):747-749

为探讨罗格列酮和运动对糖尿病糖脂代谢紊乱的干预作用,选用3～4周龄NOD小鼠作为实验材料,分别施加罗格列酮和中等强度有氧耐力运动。通过观察小鼠外在表现、体重和腹部脂肪变化以及胰腺病理切片,检测血清胰岛素水平、血液生化指标,显示罗格列酮和有氧运动对糖尿病糖脂代谢紊乱具有良性干预作用。  相似文献   

运动性骨骼肌线粒体脂肪氧化对脂肪代谢的影响     

张媛  漆正堂  丁树哲 《武汉体育学院学报》2008,42(2):56-61

脂肪在人体内的贮存量比糖丰富,但机体氧化脂肪酸的能力有限,限制利用贮存脂肪的原因至今尚未完全阐明.线粒体脂肪氧化作为脂肪代谢的限速步骤,从许多方面影响机体FA氧化,如线粒体肉碱酰基转移酶(CPT)系统、多种线粒体膜结合蛋白、磷酸腺苷活化蛋白激酶(AMPK),运动对其影响的研究结果不一.在此综述骨骼肌线粒体脂肪氧化对脂肪代谢的作用以及运动对其的影响.  相似文献   

补脾活血中药对小鼠运动时物质代谢机能的影响   总被引：24，自引：2，他引：22  

曹建民  冯炜权 《北京体育大学学报》1995,(1)

利用补脾活血中药灌服小白鼠结合游泳训练，实验结果表明，6周游泳训练对小鼠的血清睾酮水平没有显著影响，训练结合补脾及补脾活血中药的灌眼，可显著提高小鼠血清睾酮水平；服药组可显著提高小鼠肌糖原含量，加速肌糖原的恢复；服药组使小鼠血清β－脂蛋白、总胆固醇、游离胆固醇含量显著低于训练及安静组。揭示服药可明显改善机体脂蛋白和脂代谢能力；眼药组可使血液脂肪酸（FFA）含量及FFA／白蛋白比值显著低于训练及安静组；服药组可显著降低血清胆红素、谷草转氨酶（GOT）活性，揭示服用中药可明显改善肝脏物质代谢能力，加速肝功能的恢复；在所有服药组中，补脾活血组效果较单独补脾和活血组为好。  相似文献   

锌对力竭运动时大鼠肝脑组织自由基代谢的影响   总被引：13，自引：0，他引：13  

张平  李明学  李岚 《体育科学》2005,25(5):63-64

以大鼠力竭性运动为模型，观察锌对力竭运动时肝和脑组织中自由基代谢的影响。结果显示：力竭运动后即刻，肝、脑组织的MDA和SOD显著下降。补充锌能使力竭运动时肝、脑组织的MDA明显降低，阻止SOD下降，并使大鼠运动至力竭的时间稍有延长。提示，力竭运动使大鼠肝、脑组织中的自由基代谢加强。锌在大鼠肝、脑组织中具有很强的抗氧化作用，从而消除运动时产生的过量自由基。  相似文献   

低氧运动调控PPARα表达的研究述评          下载免费PDF全文

鞠丽丽 《河北体育学院学报》2016,30(6):77-81

过氧化物酶体增殖物激活受体α(PPARα)是参与调控脂代谢、抑制炎症反应和促进脂肪细胞分化的重要细胞核受体.而低氧运动可通过激活一系列分子应答机制,促进机体不同组织PPARα表达及其介导的信号分子通路重新整合,从而改变机体脂代谢体系.利用文献资料法,梳理低氧刺激对机体PPARα表达影响的相关研究,总结不同组织PPARα对其低氧运动产生代偿性适应的可能分子机制,旨在更好地解释低氧环境下运动机体PPARα在调控脂代谢中的作用.  相似文献   

Effect of fangchinoline on oxidant status in male albino rats with streptozotocin-induced diabetes     

《Electronic Journal of Biotechnology》2021

BackgroundDiabetes is a metabolic disorder caused by defects in insulin production and activity. During disease progression, changes in lipid peroxidation cause structural modifications via production of free radicals. Fangchinoline is a well-known alkaloid present in Stephaniae tetrandrine S. Moore, which has demonstrated antioxidant, anticancer, and anti-inflammatory activities.ResultsThe present study analyzed the anti-diabetic and antioxidant effects of fangchinoline in male rats with streptozotocin-induced diabetes. Rats were divided into the following groups: normal control, diabetic, diabetic + fangchinoline 100 mg/kg, diabetic + fangchinoline 200 mg/kg and diabetic + glibenclamide 600 µg/kg. The treatment was administered orally for 45 consecutive days. Lipid peroxidation was substantially increased by >50% in the serum, as well as the liver, kidney, and heart tissues of diabetic rats. However, fangchinoline supplementation significantly reduced lipid peroxidation to near normal levels. Reactive oxygen species levels were substantially increased by >500% in the serum, as well as the liver, kidney, and heart tissues of diabetic rats. Fangchinoline supplementation reduced reactive oxygen species to near normal levels. Fangchinoline supplementation significantly improved superoxide dismutase, glutathione peroxidase, catalase, and reduced glutathione levels in diabetic rats. Total hexoses, sialic acid, hexosamines, and fucose were increased in diabetic rats, whereas fangchinoline supplementation significantly reduced these total hexoses, sialic acid, hexosamines, and fucose to near normal levelsConclusionsSupplementation with fangchinoline led to significant attenuation of the levels of lipid peroxidation, ROS, and glycoprotein components such as total hexoses, hexosamines, sialic acid, and fucose, while improving antioxidant marker levels.How to cite: Xia J, Huang W, Zhou F. Effect of fangchinoline on oxidant status in male albino rats with streptozotocin-induced diabetes. Electron J Biotechnol 2021;53. https://doi.org/10.1016/j.ejbt.2021.07.005  相似文献   

Effects of α-tocopheryl acetate supplementation in preslaughter diet on antioxidant enzyme activities and fillet quality of commercial-size Sparus macrocephalus     

Zhang XD  Wu TX  Cai LS  Zhu YF 《Journal of Zhejiang University. Science. B》2007,8(9):680-685

This study examined the effects of dietary α-tocopheryl acetate supplementation on antioxidant enzyme activities and fillet quality in commercial-size Sparus macrocephalus. Three hundred fish [main initial weight （350±12） g] were divided into three groups （E250, E500 and El000） and reared in 9 cages. The fish were fed for 8 weeks with three diets containing different levels of dietary α-tocopheryl acetate （289, 553, 1069 mg/kg）. Over the experimental period, fish were fed to satiation and reached a final mean weight of （465±28） g without significant body weight difference and proximate composition difference. Fillet α-tocopherol was significantly （P〈0.05） different between groups, reaching levels of 14.2, 22.1, 30.9 pg/mg fillet for groups E250, E500 and El000, respectively. Total serum superoxide dismutase （SOD） activity increased significantly （P〈0.05） in fish fed the diets high in α-tocopheryl acetate, but serum glutathione peroxidase （GPX） activity was unaffected. In storage on ice, fillets of fish fed the diets high in α-tocopheryl acetate exhibited significantly lower （P〈0.05） levels of oxidation. These results suggested that increased dietary α-tocopheryl acetate could increase its flesh deposition, increase the activity of SOD and prevent lipid peroxidation ofSparus macrocephalus fillets in retail storage on ice.  相似文献   

金樱子多糖对药物性肝损伤小鼠血脂代谢的影响     

皮朝琼  真义才  蔡珊兰  皮建辉 《怀化学院学报》2011,30(11):36-38

为探讨金樱子多糖（RP）对药物性肝损伤小鼠血脂代谢的影响,采用KM小鼠为研究动物,将小鼠平均分为5组（高、中、低剂量组、正常组、模型组）,RP连续灌喂5周．其中第5周的星期一、三、五、日在正常灌胃后2h,除正常组外,其余4组均按5mL／kg腹腔注射0．5％CCl4的花生油溶液,并于末次注射CCl4后18h摘眼球取血,测...  相似文献   

牛磺酸对疲劳运动大鼠心肌线粒体脂质过氧化水平及GSH含量的影响   总被引：2，自引：0，他引：2  

刘铁民  李怀英 《四川体育科学》1999,(2):8-9

为探讨牛磺酸对运动机体的作用,本研究以力竭游泳大鼠为运动疲劳模型,观察了牛磺酸对心肌线粒体中ＭＤＡ及ＧＳＨ含量的影响。结果表明,牛横酸有显著抑制疲劳运动条件下心肌线粒体脂质过氧化水平及提高ＧＳＨ含量的作用。这可能是其线粒体膜保护机制之一。  相似文献   

太极拳运动对2型糖尿病患者血脂成分及胰岛素抵抗的影响   总被引：2，自引：0，他引：2  

蒋荣康 《搏击·武术科学》2007,4(10):35-36

为了进一步揭示太极拳锻炼对2型糖尿病影响的机制,文章以16名中老年肥胖者为对象,观察了太极拳锻炼前后血脂成分和胰岛素敏感性等指标的变化,经过20周太极拳运动后,患者血清TG、LDL-C、GHbA1c、FPG等成分明显降低,HDL-C水平则明显升高(p<0.01),ISI明显下降,说明太极拳运动可以改善2型糖尿病患者血脂成分,有助于胰岛素抵抗功能的改善。  相似文献