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1.
M. Halim Eshrat 《Indian journal of clinical biochemistry : IJCB》2003,18(2):54-63
InAyurvedic system of medicine in India, not only extracts of one plant or the other but also a combination of plant extracts are used
for the treatment of diabetes mellitus. The present paper reports the combined effect ofAbroma augusta andCoccinia indica known to be useful for the treatment of diabetes in Ayurveda on the fasting blood sugar, glucose tolerance and lipid profile
of Streptozotocin (STZ) induced albino rats. 300mg of water extract of the mixture of dried powdered roots ofA. augusta and leaves ofC. indica in equal proportions was given once daily for 8 weeks. After 8 weeks of treatment of Streptozotocin (STZ) diabetic rats,
the fasting blood sugar came down to almost normal value and improvement in glucose tolerance and serum lipid profile were
also observed. 相似文献
2.
Dietary spice components ofCurcuma longa andAbroma augusta have been screened for their protective effect against reactive oxygen species induced lipid peroxidation. They have been
found to be efficient antioxidant when administered in combination. The purpose of the study was to investigate the effect
of oral administration (300mg/Kg) of the aqueous extract of turmeric whose active ingredient isCurcumin andAbromine powder as a hypoglycemic agent mixed with diet. The effect of this aqueous extract on blood glucose, lipid peroxidation (LPO)
and the antioxidant defense system in rat tissues like liver, lung, kidney and brain was studied for 8 weeks in streptozotocin
induced diabetic rats. The administration of an aqueous extract of turmeric and abromine powder resulted in a significant
reduction in blood glucose and an increase in total haemoglobin. The aqueous extract also resulted in decreased free radical
formation in the tissues studied.
The decrease in thiobarbituric acid reactive substances (TBARS) and increase in reduced glutathione (GSH), superoxide dismutase
(SOD) and catalase (CAT) clearly showed the antioxidant property of the mixture. It is suggested that these changes initially
counteract the oxidative stress in diabetes however, a gradual decrease in the antioxidative process may be one of the factors
which results in chronic diabetes. These results indicate that the mixture of the two plants have shown antidiabetic activity
and also reduced oxidative stress in diabetes. A combination ofAbroma augusta and Curcuma longa also restored the other general parameters in diabetic animals. The results were statistically analyzed and indicated that
combination of herbal extracts showed better efficacy as compared to individual herbal plant extracts used. 相似文献
3.
Halim Eshrat M. Ali Hussain 《Indian journal of clinical biochemistry : IJCB》2002,17(2):115-123
This study was carried out to investigate the effect of oral feeding of water extract of fresh leaves ofAzadirachta indica (Fam:Meliaceae) in streptozotocin induced diabetes and its associated retinopathy in rats. Treatment of the diabetic rats with aqueous extract of leaves ofA. indica at a dose of 250 mg/kg body weight for 16 weeks resulted in gradual but significant fall in blood glucose and improvement in serum total, LDL and HDL cholesterol and triacylglycerol which increased in diabetic rats. It also showed improvement in body weight and reversed retinopathy. 相似文献
4.
Y. K. Murali Ramesh Chandra P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》2004,19(2):202-204
Water extract of dry fruits ofTerminalia chebula (Hindi-Harda, Telugu-Karakkaya) at a dose of 200 mg/kg body weight improved the glucose tolerance as indicated by 44% of
reduction in the peak blood glucose at 2nd hour in glucose tolerance test in diabetic (streptozotocin induced) rats. Treatment of diabetic rats with an initial fasting
blood glucose of 253±9.4 mg/dl daily once with the water extract (200 mg/kg) for two weeks brought down the fasting blood
glucose to 123±8.4 mg/dl which is only slightly above the normal value. These results indicate that water extract of Terminalia
chebula improves glucose tolerance and brings down fasting blood glucose in diabetic rats. 相似文献
5.
Eshrat Halim M. A. Hussain Kaiser Jamil Mala Rao 《Indian journal of clinical biochemistry : IJCB》2001,16(2):190-194
Effect of oral administration of 200 mg/Kg body weight of the aqueous extract ofOcimum sanctum (Tulsi) mixed with diet for eight weeks to diabetic (streptozotocin induced) rats was studied. There was significant reduction
in fasting blood glucose, serum lipid profile, lipid peroxidation products, (LPO) and improvement in glucose tolerance. The
aqueous extract also decreased LPO formation (thiobarbituric acid reactive substances TBARS) and increased antioxidant enzymes
superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione transferase (GT) and one antioxidant
reduced glutathione (GSH) in plasma and rat liver, lung, kidney and brain. The decrease in TBARS and increase in GSH, SOD,
CAT, GPX, and GT clearly shows the antioxidant property ofOcimum sanctum. 相似文献
6.
Eshrat M. Halim A. K. Mukhopadhyay 《Indian journal of clinical biochemistry : IJCB》2006,21(2):181-188
This study was carried out to see the effect of the aqueous extract ofOcitum sanctum Linn (Tulsi) with Vitamin E on biochemical parameters and retinopathy in the streptozotocin-induced diabetic albino male
rats. Adult albino male rats weighing 150–200 gm were made diabetic by intraperitoneal injection of streptozotocin in the
dose 60 mg/kg in citrate buffer (pH 6.3). The diabetic animals were left for one month to develop retinopathy. Biochemical
parameters like plasma glucose, oral glucose tolerance and glycosylated hemoglobin HbA1c, were measured along with lipid profile, and enzymes like glutathione peroxidase (GPX), lipid peroxidase (LPO), superoxide
dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) in normal, untreated diabetic rats and diabetic rats treated
withOcimum sanctum L extracts and vitamin E. Fluorescein angiography test was done for assessing retinopathy. Results on biochemical parameters
were analyzed statistically by using ANOVA followed by Dunnet's ‘t’-test. A p-value of <0.05 was considered as significant.
Evaluation of biochemical profile in treated groups showed statistically significant reduction in plasma levels of glucose,
HbA1c, lipid profile and LPO, and elevation of GPX, SOD, CAT and GST. Treatment of the diabetic animals withOcimum sanctum and Vitamin E, alone and in combination for 16 weeks showed reversal of most of the parameters studied including plasma glucose
levels. Angiography showed improvement in retinal changes following combined antidiabetic treatment. 相似文献
7.
Dolly Jaiswal Prashant Kumar Rai Amit Kumar Geeta Watal 《Indian journal of clinical biochemistry : IJCB》2008,23(2):167-170
The present study deals with the evaluation of glycemic profile of aqueous extract of Cajanus cajan leaves in streptozotocin induced type 2 diabetic rats. Single oral administration of graded doses of aqueous extract of Cajanus
cajan leaves showed significant increment of 14.3 % in fasting blood glucose levels of normal rats. The sub diabetic and mild diabetic
models have also shown hyperglycemic effect from the same variable doses of the extract. The dose of 1000 mg/kg showed the
maximum rise of 17.1, 71.2 and 50.7 % in Blood glucose levels of normal, sub and mild diabetic rats respectively during glucose
tolerance test. The study of leaves was taken into consideration on the basis of earlier reported hypoglycemic activity of
Cajanus cajan seeds. However the results observed were found just opposite and therefore it may be useful in controlling hypoglycemia,
occasionally caused due to excess of insulin and other hypoglycemic drugs. 相似文献
8.
P. Pavana S. Sethupathy S. Manoharan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):77-83
The aim of the present study was to evaluate the antihyperglycemic and antilipidperoxidative effects of ethanolic seed extract
ofTephrosia purpurea (TpEt) in streptozotocin induced diabetic rats. Hyperglycemia associated with an altered hexokinase and glucose 6 phosphatase
activities, elevated lipid peroxidation, disturbed enzymatic and non-enzymatic antioxidants status were observed in streptozotocin
induced diabetic rats. Oral administration of “TpEt” at a dose of 300mg/kg bw showed significant antihyperglcemic and antilipidperoxidative
effects as well as increased the activities of enzymatic antioxidants and levels of non enzymatic antioxidants. We also noticed
that the antihyperglycemic effect of plant drug (TpEt) was comparable to that of the reference drug glibenclamide. Our results
clearly indicate that “TpEt” has potent antihyperglycemic and antilipidperoxidative effects in streptozotocin induced diabetic
rats and therefore further studies are warranted to isolate and characterize the bioactive antidiabetic principles from “TpEt”. 相似文献
9.
Abbas Ali Mahdi Anu Chandra Raj Kumar Singh Sanjeev Shukla L. C. Mishra Sohail Ahmad 《Indian journal of clinical biochemistry : IJCB》2003,18(2):8-15
In the present study the antioxidative potential ofMomordica charantia, Azadirachta indica, Allium sativum andOcimum sanctum was assessed in streptozotocin induced diabetic rats. Lipid peroxide levels were also measured in normal, diabetic and treated
animals. Malondialdehyde (MDA) levels were significantly higher and antioxidant activity was found low in diabetic groups
as compared to the control groups, and significant alteration in both the MDA levels and antioxidant activity was also observed
when the above herbal hypoglycemic agents were given to diabetic rats. On the basis of our results we conclude thatM. charantia, A. indica, A. sativum andO. sanctum are not only useful in controlling the lipid peroxide levels but are also helpful in further strengthening the antioxidant
potential. 相似文献
10.
Jyoti Sethi Sushma Sood Shashi Seth Anjana Talwar 《Indian journal of clinical biochemistry : IJCB》2004,19(2):152-155
Ocimum sanctum leaves have been traditionally used in treatment of diabetes mellitus. Dietary supplementation of fresh tulsi leaves in a
dose of 2 gm/kg BW for 30 days led to significant lowering of blood glucose levels in test group. Intake ofOcimum sanctum also led to significant increase in levels of superoxide dismutase, reduced glutathione and total thiols, but marked reduction
in peroxiodised lipid levels as compared to untreated control group. The leaves were found to possess both superoxide and
hydroxyl free radical scavenging action. The present observations establish the efficacy ofOcimum sanctum leaves in lowering blood glucose levels and antioxidant property appears to be predominantly responsible for hypoglycemic
effect. 相似文献
11.
Vishnu Kumar A. K. Khanna M. M. Khan Ranjana Singh Sushma Singh Ramesh Chander Farzana Mahdi J. K. Saxena Shweta Saxena V. K. Singh R. K. Singh 《Indian journal of clinical biochemistry : IJCB》2009,24(1):65-69
The present study was carried out to evaluate the hypoglycemic, lipid lowering and antioxidant activities in root extract
of Anthocephalus indicus (A indicus) in alloxan inducd diabetic rats. Oral administration of ethanol extract of root (500mg/
kg body weight) for 21 days resulted in significant decrease in the levels of blood glucose, triglycerides, total cholesterol,
phospholipid and free fatty acids. Furthermore, the root extract (100–400μg) inhibited the generation of superoxide anions
and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The result of the present study demonstrated hypoglycemic,
lipid lowering and antioxidant activities in root extract of A indicus, which could help in prevention of diabetic dyslipidemia
and related diseases. 相似文献
12.
Amar B. Singh J. P. Chaturvedi T. Narender Arvind K. Srivastava 《Indian journal of clinical biochemistry : IJCB》2008,23(4):391-393
Peganum harmala L. (Zygophyllaceae) is a traditional medicine used for the treatment of variety of human ailments, including
antidepression, hallucination, antileishmaniasis etc. We report for first time the hypoglycemic activity of the ethanolic
extract of this plant at two dose levels of 150 and 250mg/kg bw in sucrose challenged normal as well as in rats with streptozotocin
induced diabetes. The oral administration of ethanolic extract causes maximum fall of blood glucose level to 22.9% (p<0.05)
and 29.4% (p<0.01) respectively with the two doses in normal and 30.3% (p<0.01) and 48.4% (p<0.001) in diabetic rats. The
standard drug metformin treated group showed 28.0% (p<0.01) and 45.5% (p<0.001) respectively in normal and diabetic rats.
The above results show that the ethanolic extract of P. harmala is as effective as metformin in reducing the blood glucose
levels of normoglycemic and streptozotocin-induced diabetic rats. 相似文献
13.
M. I. Akpanabiatu I. B. Umoh E. O. Udosen A. E. Udoh E. E. Edet 《Indian journal of clinical biochemistry : IJCB》2005,20(2):29-34
Aqueous extract of the leaf and root ofNauclea latifolia Sm. (Rubiaceae) is used in Nigerian folk medicine for the treatment of hypertension. This work is carried out to investigate
the effect ofNauclea latifolia leaf extract on lipid profile and cardiovascular activity of rats. Normal and 10% coconut oil fed rats were treated with
the water-soluble fraction of the ethanol extract ofNauclea latifolia leaf for 2 weeks. Forty-eight mature male albino rats of the Wistar strain were divided into two experiments of four groups,
each group having 6 animals. Experiment I animals were treated with the water-soluble fraction of the ethanol extract whilst
experiment II animals were fed 10% coconut oil meal before treatment with the water-soluble fraction of the ethanol extract.
A single oral dose ofNauclea latifolia was 170, 340 and 510 mg/kg body wt/day of the extracts respectively for 2 wks. There was no significant change in the lipid
profile of the experimental animals as compared with the controls. There was about 40% relaxation on contracted thoracic aorta
that was pre-contracted with 2 μM phenylephrine. The viability of the tissue was tested against 10 μM of acetylcholine. There
was no significant (P>0.05) change in Na+ concentration in the serum. However, the K+ concentration in the serum of the experimental animals showed a significant increase. The study shows that ethanol extract
ofNauclea latifolia has vasodilator action on the aorta and that lipid profiles of experimental rats were not affected. Furthermore, the increase
in the K+ may be contributing to the vasodilator effect ofNauclea latifolia. 相似文献
14.
S. Gupta R. Shukla K. M. Prabhu S. Aggrawal U. Rusia P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》2002,17(1):58-63
Acute and chronic toxicity studies were conducted to assess toxicity of a partially purified preparation from the water extract
of the bark ofFicus bengalensis, which was demonstrated in our earlier studies to have significant hypoglycemic and hypocholesteroiemic effect on alloxan
induced, mild and severe diabetes in rabbits. LD50 of this preparation was found to be ∼1 gm/kg in rats when given orally. For chronic toxicity studies 3 doses of aqueous preparation
were given to 3 groups of rats. First group received 5 times ED50 (50 mg/kg), second group 10 times ED50 (100 mg/kg) and the third group 15 times ED50 (150 mg/kg) for 3 months. Fourth group which served as control was given water. After three months, blood was collected for
studying biochemical and hematological parameters. Blood glucose, serum cholesterol, liver and kidney function tests, haemoglobin,
total and differential leukocyte count were determined. Animals were sacrificed and histopathological examination of liver,
heart and kidneys was carried out. Results of the study showed that partially purified preparation fromFicus bengalensis is not toxic by all the above mentioned parameters. 相似文献
15.
P Renuka Devi S Krishna Kumari C Kokilavani 《Indian journal of clinical biochemistry : IJCB》2007,22(1):143-147
The effect of the oral administration ofVitex negundo leaf extract on the levels of enzymic and non-enzymic antioxidants were studied in the adjuvant induced arthritic (AIA) rats
The levels of antioxidant enzymes such as SOD, CAT, GPx, G6PD, GSH and Vit-C were estimated in various groups of the experimental
rats. It was observed that the antioxidant enzyme levels in the AIA were significantly low when compared to normal rats. A
significant decrease in enzymic antioxidant—SOD, CAT, GPx, G6PD and non-enzymic antioxidant—GSH, Vit-C were observed in the
liver of AIA rats compared to the normal rats. These results suggest that the leaf extract ofVitex negundo possesses antioxidant activity. 相似文献
16.
Dolly Jaiswal Prashant Kumar Rai Geeta Watal 《Indian journal of clinical biochemistry : IJCB》2009,24(1):88-93
The present study defines the systematic evaluation and the role of minerals in glycemic potential of aqueous extract of Withania
coagulans fruits in order to develop an effective and safe alternative treatment for diabetes mellitus. Laser Induced Breakdown
Spectroscopy was used for glycemic element detection. The study is based on the results of lowering in blood glucose levels
of normal, sub, mild and severely diabetic rats assessed during fasting blood glucose, glucose tolerance test and post prandial
glucose studies. The dose of 1000mg/ kg was identified as the most effective dose, which reduces the Fasting Blood Glucose
level maximum by 33.2% at 4h in normal rats during fasting blood glucose studies. Glucose tolerance test studies of normal,
sub and mild diabetic rats showed the maximum reduction of 15.7, 28.9 and 37.8% at 3h respectively. Long-term study in case
of severely diabetic rats showed reduction of 52.9 and 54.1% in Fasting Blood Glucose and Post Prandial Glucose levels respectively
after 30 days of treatment. The present study, besides confirming hypoglycemic and antidiabetic activities of aqueous extract
of W. coagulans, helps in identifying the role of trace minerals like Mg & Ca responsible for antidiabetic potential of this
potent indigenous shrub. 相似文献
17.
The present study was carried out to evaluate the antidiabetic effect of T. arjuna stembark extract and to study the activities
of hexokinase, aldolase and phosphoglucoisomerase, and gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1,6-diphosphatase
in liver and kidney of normal and alloxan induced diabetic rats. Oral administration of ethanolic extract of bark (250 and
500mg/kg body weight) for 30 days, resulted in significant decrease of blood glucose from 302.67±22.35 to 82.50±04.72 and
in a decrease in the activities of glucose-6-phosphatase, fructose-1,6-disphosphatase, aldolase and an increase in the activity
of phosphoglucoisomerase and hexokinase in tissues. However, in the case of 250 mg/kg body weight of extract, less activity
was observed. The study clearly shows that the bark extract ofT. arjuna possesses potent antidiabetic activity. 相似文献
18.
Santosh Kumar Singh Achyut Narayan Kesari Prashant Kumar Rai Geeta Watal 《Indian journal of clinical biochemistry : IJCB》2007,22(2):48-52
The present study reveals the effect of Musa paradisiaca stem juice on blood glucose level (BGL) of normal & diabetic rats.
The dose of 500 mg/kg bodyweight produces a significant rise of 28.3% in blood glucose level after 6h of oral administration
in normal rats. Whereas, in sub diabetic rats the same dose produces a rise of 16.4% in blood glucose levels within 1h during
glucose tolerance test (GTT) and a rise of 16% after 4 h in fasting blood glucose levels of severe diabetic cases. These results
were unexpected and important to report as other species of Musa like Musa sapientum has been reported for its hypoglycemic
effect. 相似文献
19.
Arun Ray Susri Ray Chaudhuri Biswajit Majumdar Sandip K. Bandyopadhyay 《Indian journal of clinical biochemistry : IJCB》2002,17(2):44-51
Oral administration of ethanol extract of the rhizome ofPirorhiza kurroa at a dose of 20mg/kg body weight, for 10 consecutive days, was found to enhance the rate of healing on Indomethacin-induced
gastric ulcer in rats, compared to the ulcerated group without treatment. The level of peroxidised lipid, in terms of thiobarbituric
acid reactive species (TBARS), in gastric tissue, was increased in ulcerated rats which was restored to near normalcy on treatment
with ethanol extract. The specific activity ofin vivo antioxidant enzymes, viz SOD and catalase and total tissue sulfhydryl (thiol) group, which were markedly decreased in ulcerated
group, were found to be significantly elevated (p<0.05), on treatment with the above extract, at the specified dose, compared
to the indomethacin—induced ulcerated group without any supporting treatment. The present study thus suggests that the ethanol
extract of rhizome ofPicrorhiza kurroa, at the dose of 20mg/kg body weight, accelerated the healing of stomach wall of indomethacin induced gastric ulcerated rats
by anin vivo free radical scavenging action. 相似文献
20.
Subbiah Pugazhenthi P. Suryanarayana Murthy 《Indian journal of clinical biochemistry : IJCB》1995,10(1):19-22
A new method was developed to purify partially an orally active hypoglycemic fraction from the unripe fruits ofMomordica charantia Linn. The residue after centrifugation of the fruit juice was extracted with ethanol and the concentrated ethanolic extract was further extracted with diethyl ether. In normal rabbits after oral administration, the ether extract at a dose of 0.75 g/kg body wt decreased the fasting blood glucose by 26% (P<0.01). It was compared with charantin, the isolation procedure of which led to loss of hypoglycemic activity many times. Our new method of isolation is simple and the hypoglycemic effect is retained more consistently after purification. 相似文献