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目的：研究ＭＣＩ－１５４对失血性休克大鼠肝脏结构和超微结构的影响,方法：利用大鼠失血性休克模型,设立ＭＣＩ－１５４治疗组和生理盐水对照组,观察大鼠肝脏结构和超微结构的改变。结果：对照组可见有较多的溶解性坏死灶,肝细胞胞浆疏松,肿胀,线粒体数量减少,基质密度增加,部分出现嵴消失,内质网显示扩张,颗粒明显减少;治疗组仅偶见有小灶性溶解性坏死,肝细胞线粒体肿胀,个别显示嵴模糊,基质密度增加,数量未见明显 相似文献
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MCI—154对失血性休克大鼠心肌结构和超微结构的影响 总被引：1，自引：0，他引：1
目的：研究ＭＣＩ－１５４对失血性休克大鼠心肌结构和超微结构的影响。方法：利用大鼠失血性休克模型,设立ＭＣＩ－１５４治疗组和生理盐水对照组,观察大鼠心肌结构和超微结构的改变。结果;对照组大鼠心肌出现局灶性心肌纤维深解破坏,肌浆网有不同程度的肿胀扩张,线粒体出现基质密度加深,嵴模型,线粒体数量有所减少;治疗组见有少部分线粒体出现基质密度增高,部分显示嵴模型或消失,线粒体数量未见减少,肌小节结构清晰,偶 相似文献
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对小鼠艾氏腹水癌细胞及人直肠粘液腺癌在深低温（－１９６℃）冷冻前后的功能和超微结构进行了比较研究，结果表明，与对照组相比，两种癌细胞的ＦＤＡ荧光哟度和＾３Ｈ－ＴｄＲ掺入率显著降低（Ｐ＜０．０１），乳酸脱氢同工酶的Ｍ亚基显著增加，Ｈ亚基明显减少，，Ｍ／Ｈ比值提高，电镜观察到癌细胞内和核内形成空泡，胞质凝缩，线粒体膨胀，核膜破裂，核质外流，染色质凝集呈块状不均匀分布等超微结构。说明深低温冷冻对肿瘤细胞 相似文献
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《黑龙江科技信息》2017,(4)
研究观察苯对小鼠骨髓嗜多染红细胞微核的影响,对苯的遗传毒性进行评价。将小鼠随机分为阴性对照组、阳性对照组及低浓度、中浓度、高浓度、3个剂量共5组,每组10只,雌雄各半,采用静式吸入染毒法,3个剂量组每天染毒1次。连续30d。2个对照组放置在另一个染毒柜中,除不染毒外其余处理均同染毒组。阳性对照组小鼠于处死前1d腹腔注射环磷酰胺(60mg/kg/B·W)1次。30d后处死小鼠,采用常规微核实验方法,检测小鼠骨髓嗜多染红细胞微核。以微核率为指标,进行方差分析,判断苯对小鼠骨髓嗜多染红细胞微核的影响。实验组组的微核率要高于阴性和阳性对照组,高剂量组的微核率最高!实验中的苯试剂可促进小鼠骨髓嗜多染红细胞产生微核,具有遗传毒性,且高浓度的苯毒性最强。 相似文献
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目的 利用链脲佐菌素（STZ）联合高脂饮食复制2型糖尿病小鼠模型,观察茶多糖对小鼠血清生化指标的影响.方法 90只小鼠给予高脂饮食4周后腹腔注射STZ建立2型糖尿病模型,随机分成模型组、茶多糖高中低三个剂量组以及阳性药二甲双胍组,另取10只为正常对照组.茶多糖组、阳性对照组分别按照计量灌胃治疗,对照组和模型组给予等体积的蒸馏水灌胃.4周后,检测小鼠血清空腹血糖、胰岛素、甘油三酯、总胆固醇以及糖耐量等指标.结果 4周后,茶多糖中高剂量组空腹血糖、甘油三酯以及总胆固醇均比模型组低（P＜0.05,P＜0.01）,而给药组血清胰岛素水平比模型组高（P＜0.05,P＜0.01）,并且给药组与模型组比较小鼠糖耐量有所改善（P＜0.05,P＜0.01）.结论 茶多糖能够降低2型糖尿病小鼠血糖,并且能够改善脂类代谢. 相似文献
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《西藏科技》2021,(4)
目的观察藏药九味麝香丸的抗炎和免疫干预药效,为其临床应用提供参考。方法九味麝香丸0.20g/kg、0.10g/kg、0.05g/kg灌胃给予7天,观察药物对二甲苯所致小鼠耳肿胀及小鼠棉球肉芽肿形成的影响;九味麝香丸0.20g/kg、0.10g/kg、0.05g/kg灌胃给予13天,观察药对2,4-二硝基氟苯(DNFB)所致小鼠迟发型超敏反应和鸡红细胞所致小鼠溶血素生成的影响。结果藏药九味麝香丸0.20g/kg、0.10g/kg可抑制二甲苯所致小鼠耳肿胀,耳肿胀度和肿胀率均降低,肿胀度与模型对照组比较差异有统计学意义(P0.05,P0.01),提示其具有抑制急性炎症作用;0.20g/kg可使小鼠棉球肉芽干重降低,与模型对照组比较差异有统计学意义(P0.05),提示其对亚急性炎症也有一定抑制作用;0.20g/kg、0.10g/kg可增强DNFB所致小鼠迟发型超敏反应,0.20g/kg组耳肿胀度和肿胀率均增高,与模型对照组比较差异有统计学意义(P0.05,P0.01)。结论藏药九味麝香丸具有抗炎和免疫增强药效。 相似文献
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长期高血糖导致糖尿病患者的氧化应激,引起胰岛β细胞氧化损伤,但核转录因子Nrf2(NF-E2-related factor 2)抵抗胰岛β细胞氧化损伤的作用机制还不清楚.本研究用低浓度葡萄糖(LG,5.6 mmol/L)、LG+H2O2和高浓度葡萄糖(HG,27.6 mmol/L)分别处理小鼠胰岛NIT-1β细胞48 h,检测细胞内活性氧(ROS,reactive oxygen species)生成、胰岛素合成与分泌变化和Nrf2入核表达水平.研究发现,高糖诱导NIT-1β细胞的ROS生成,降低细胞合成与分泌胰岛素的水平,但Nrf2入核表达降低胰岛β细胞氧化应激.结果提示Nrf2入核表达可以抵抗高糖诱导的胰岛β细胞氧化损伤,改善细胞合成与分泌胰岛素的功能. 相似文献
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A research group led by Prof. ZHAI Qiwei from the Institute for Nutritional Sciences under the CAS Shanghai Institutes for Biological Sciences has discovered that even relatively low doses of resveratrol-a chemical found in the skins of red grapes in red wine-can improve the sensitivity of mice to the hormone insulin according to a report in the October issue of Cell Metabolism.…… 《中国科学院院刊(英文版)》2008,22(1):14-15
Aresearch group led by Prof. ZHAI Qiwei from the Institute for Nutritional Sciences under the CAS Shanghai Institutes for Biological Sciences has discovered that even relatively low doses of resveratrol--a chemical found in the skins of red grapes and in red wine--can improve the sensitivity of mice to the hormone insulin, according to a report in the October,2007 issue of Cell Metabolism. As insulin resistance is often characterized as the most critical factor contributing to the development of Type 2 diabetes, the findings“provide a potential new therapeutic approach for preventing or treating” both conditions, the researchers said. 相似文献
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Marjorie Armstrong-Stassen Margaret Landstrom Ramona Lumpkin 《The Information Society》1998,14(2):153-164
This study examined how students who had no prior experience with videoconferencing would react to the use of videoconferencing as an instructional medium. Students enrolled in seven different courses completed a questionnaire at the beginning of the semester and again at the end of the semester. Students at the origination and remote sites did not differ in their reactions toward videoconferencing but there was a significant difference for gender. Women reacted less favorably to videoconferencing. Compared to the beginning of the semester, students reported significantly less positive attitudes toward taking a course through videoconferencing at the end of the semester. There were no significant differences in students' attitudes toward videoconferencing across courses at the beginning of the semester but there were significant differences across the courses at the end of the semester. The results suggest the need for better preparation for both students and instructors. 相似文献
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A joint study by Prof. ZHANG Zhibin from the CAS Institute of Zoology his co-workers from Norway US Swiss have indicated that historical outbreaks of migratory locusts in China were associated with cold spells suggesting that China's projected climate warming could decrease the pest's numbers. The study was published in Proceedings of the National Academy of Sciences on September .…… 《中国科学院院刊(英文版)》2008,22(1):6-7
Ajoint study by Prof. ZHANG Zhibin from the CAS Institute of Zoology and his co-workers from Norway, US and Swiss have indicated that historical outbreaks of migratory locusts in China were associated with cold spells, suggesting that China＇s projected climate warming could decrease the pest＇s numbers. The study was published in Proceedings of theNational Academy of Sciences on 17 September, 2007. 相似文献
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Caroline Haythornthwaite 《The Information Society》2001,17(3):211-226
A computer-mediated group is a complex entity whose members exchange many types of information via multiple means of communication in pursuit of goals specific to their environment. Over time, they coordinate technical features of media with locally enacted use to achieve a viable working arrangement. To explore this complex interaction, a case study is presented of the social networks of interactions and media use among members of a class of computer-supported distance learners. Results show how group structures associated with project teams dominated who communicated with whom, about what, and via which media over the term, and how media came to occupy their own communication niches: Webboard for diffuse class-wide communication; Internet Relay Chat more to named others but still for general communication across the class; and e-mail primarily for intrateam communication. Face-to-face interaction, occurring only during a short on-campus session, appears to have had a catalytic effect on social and emotional exchanges. Results suggest the need to structure exchanges to balance class-wide sharing of ideas with subgroup interactions that facilitate project completion, and to provide media that support these two modes of interaction. 相似文献
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Active biological molecules functional structures can be fabricated into a bio-mimetic system by using molecular assembly method. Such materials can be used for the drug delivery disease diagnosis therapy new nanodevice construction.…… 《中国科学院院刊(英文版)》2008,22(1):22-22
Active biological molecules and functional structures can be fabricated into a bio-mimetic system by using molecular assembly method. Such materials can be used for the drug delivery, disease diagnosis and therapy, and new nanodevice construction. 相似文献
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《中国科学院院刊(英文版)》2008,22(1):2-3
CAS should stick to the principle of rendering service to, and giving impetus for, the development of China＇s science enterprise by making S＆T innovations, said CAS President LU Yongxiang. The CAS president made the remarks in a recent talk to communicate the gist of the winter session of the Party＇s Leading-member Group at CAS, which was held from 7 to 11 January in Beijing. 相似文献
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《中国科学院院刊(英文版)》2008,22(1)
With great care, Dr. ZHOU Zhonghe takes out a package wrapped by cotton tissue from a drawer and says: "This is the gem of our collections: the fossil of a bird that lived 125 million years ago!" Then, pointing at a tiny mound, he explains: "Look, this is the claw and that is the head. It was in the egg shell and ready to hatch ... The species fell into a family of waterside inhabitants." 相似文献
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Electronic data interchange (EDI) provides means for interorganizational communication, creates network externalities, requires an advanced information technology (IT) infrastructure, and relies on standards. In the diffusion of such innovations, institutional involvement is imperative. Such institutions contain governmental agencies, national and global standardization organizations, local government, and nonprofit private organizations like industry associations. The last type of organizations we call intermediating institutions. They intermediate or coordinate ("inscribe") the activities of a group of would-be adopters. Unfortunately, little is known of how these organizations shape the EDI diffusion trajectory. In this article we examine one specific type of intermediating organizations?industry associations?and how they advanced the EDI diffusion process in the grocery sectors of Hong Kong, Denmark and Finland. We identify six institutional measures, placed into a matrix formed by the mode of involvement (influence vs. regulation) and the type of diffusion force (supply push vs. demand pull), that can be mobilized to further the EDI diffusion. Industry associations were found to be active users of all these measures to varying degrees. Their role was critical especially in knowledge building, knowledge deployment, and standard setting. Furthermore, institutional involvement varied due to policy and cultural contingencies and power dependencies. 相似文献
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Leah A. Lievrouw 《The Information Society》2000,16(2):155-159
This essay focuses on universal service and the Internet as means to support social and political participation. The emphasis on access to telecommunications systems in conventional approaches to universal service is contrasted with access to content. A model of the information environment is described that accounts for the roles of content and conduit, both of which are necessary conditions to achieve true access. A method is outlined for employing information indicators to observe or measure the information environment. 相似文献
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Puay Tang 《The Information Society》1998,14(1):19-31
The increasing prospects of digital piracy has prompted the perceived need by electronic publishers to adopt technical systems of protection, and governments to reform their copyright laws. This article is a preliminary study of the management of intellectual property by electronic publishers, defined as those involved in the production of online databases, and CD-ROMs. It focuses on three main issues: (1) how electronic publishers view the increasing threat of piracy; (2) the methods of protection employed to protect intellectual property in digital format; and (3) the importance of technological protection of intellectual property in electronic publications. The analysis is based on a sample of 23 UK electronic publishers. The interviews revealed an interesting assortment of protection methods and did not show that technological protection was a preferred way. Instead, the means of protection, in addition to copyright law, comprised niche markets, pricing, trust, bad publicity, and nontechnical and technical means. 相似文献